Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
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DOI：
10.1038/nm.3891
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发表时间：
2015-08-01
期刊：
影响因子：
82.9
通讯作者：
Schrauwen, Patrick
中科院分区：
文献类型：
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作者：
Hanssen, Mark J. W.;Hoeks, Joris;Schrauwen, Patrick
冷暴露可能是通过增加棕色脂肪组织（BAT）的质量和活性来治疗糖尿病的潜在疗法。在这里，我们报告说，10天的冷适应（14-15摄氏度）增加外周胰岛素敏感性相似的43%，在8型糖尿病受试者。基础骨骼肌GLUT 4易位显著增加，对胰岛素信号传导或AMP活化蛋白激酶（AMPK）活化无影响，BAT葡萄糖摄取仅轻微增加。
Cold exposure may be a potential therapy for diabetes by increasing brown adipose tissue (BAT) mass and activity. Here we report that 10 d of cold acclimation (14-15 degrees C) increased peripheral insulin sensitivity by similar to 43% in eight type 2 diabetes subjects. Basal skeletal muscle GLUT4 translocation markedly increased, without effects on insulin signaling or AMP-activated protein kinase (AMPK) activation and only a minor increase in BAT glucose uptake.