Subsurface photodisruption in human sclera: wavelength dependence
Subsurface photodisruption in human sclera: wavelength dependence
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DOI：
10.3928/1542-8877-20030301-06
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发表时间：
2003-03-01
影响因子：
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通讯作者：
Mouroua, GA
中科院分区：
文献类型：
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作者：
Sacks, ZS;Kurtz, RM;Mouroua, GA
背景和目的：全世界约有1.05亿人患有青光眼，约有500万人因其并发症而失明。目前的手术技术经常失败，因为结膜组织，特农组织，或两者的疤痕。飞秒激光可以在组织表面下创建高度精确的切口，如先前在透明角膜中所示。由于巩膜是一个高度散射的亚表面，光致破裂以前是不可能的。材料和方法：为了克服散射，在1，700 nm的激光操作，使亚表面切割在人巩膜在体外通过光致破裂。结果：在表面下方创建了小于10 μ m宽度的切口，没有附带组织效应，结论：在离体人类巩膜中可以实现完全亚表面的光致破裂。需要进行体内研究以评估该技术在巩膜应用中的潜在用途。
BACKGROUND AND OBJECTIVE: Approximately 105 million people worldwide have glaucoma, and approximately 5 million are blind from its complications. Current surgical techniques often fail because of scarring of the conjunctival tissue, Tenon's tissue, or both. Femtosecond lasers can create highly precise incisions beneath the surface of a tissue, as previously demonstrated in the transparent cornea. Because the sclera is a highly scattering Subsurface, photodisruption has not been previously possible.MATERIALS AND METHODS: To overcome scattering, a laser operating at 1,700 nm was used to make subsurface cuts in human sclera in vitro via photodisruption.RESULTS: Sub-10-mum width incisions were created beneath the surface without collateral tissue effects, something not possible with shorter wavelengths used to date in corneal applications with the femtosecond laser.CONCLUSION: Completely subsurface photodisruptions can be accomplished in human sclera in vitro. In vivo studies are required to evaluate the potential use of this technology for scleral applications.