Roles, regulation, and mechanism of polysialic acid function during neural development
Roles, regulation, and mechanism of polysialic acid function during neural development
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DOI：
10.1016/s0300-9084(01)01293-7
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发表时间：
2001-07-01
期刊：
影响因子：
3.9
通讯作者：
Rutishauser, U
中科院分区：
文献类型：
--
作者：
Brusés, JL;Rutishauser, U
神经细胞粘附分子（PSA-NCAM）是脊椎动物进化过程中出现的一种调节细胞相互作用的新机制。这种大而丰富的糖蛋白可以在细胞表面发挥空间效应，导致不仅由NCAM而且由各种其他粘附受体介导的细胞-细胞键的减弱。PSA-NCAM表达的变化是发育程序和生理输入的结果。这种细胞-细胞附着的全局调节已被证明有助于细胞迁移、轴突寻路和靶向以及胚胎和成人神经系统中的可塑性变化。(C)2001法国生物化学与生物分子学会/科学与医学版Elsevier SAS。All rights reserved.
The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) appeared during the evolution of vertebrates as a new mechanism for regulation of cell interactions. This large and abundant glycoprotein can exert steric effects at the cell surface that lead to the attenuation of cell-cell bonds mediated not only by NCAM but also a variety of other adhesion receptors. PSA-NCAM expression changes both as a result of developmental programs and physiological inputs. This global modulation of cell-cell attachment has been shown to facilitate cell migration, axon pathfinding and targeting, and plastic changes in the embryonic and adult nervous system. (C) 2001 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS. All rights reserved.