Lack of mutations of the p53 tumor suppressor gene in hepatocellular carcinomas induced in rats by a peroxisome proliferator.
Lack of mutations of the p53 tumor suppressor gene in hepatocellular carcinomas induced in rats by a peroxisome proliferator.
复制标题
过氧化物酶体增殖剂诱导的大鼠肝细胞癌中缺乏 p53 肿瘤抑制基因突变。
DOI：
10.1002/mc.2940070206
复制
发表时间：
1993
影响因子：
4.6
通讯作者：
Shinozuka,H
中科院分区：
文献类型：
--
作者：
Smith,ML;Yeleswarapu,L;Lombardi,B;Shinozuka,H
对长期喂食过氧化物酶体增殖剂BR931的大鼠诱发的肝细胞癌进行免疫组织化学、免疫印迹和DNA测序分析，以确定肿瘤是否携带p53基因的突变或其他改变。未检测到。因此，这种肿瘤抑制基因的失活似乎与BR931（一种非遗传毒性化学性肝癌原）的致癌性无关。
Immunohistochemical, immunoblotting, and DNA‐sequencing analyses were performed on hepatocellular carcinomas induced in rats chronically fed BR931, a peroxisome proliferator, to determine whether the tumors carried mutations or other alterations of thep53gene. None were detected. Inactivation of this tumor suppressor gene does not appear, therefore, to be involved in the carcinogenicity of BR931, a nongenotoxic chemical hepatocarcinogen.