Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass.
Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass.
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DOI：
10.1007/s00467-021-05095-8
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Klawitter J
中科院分区：
文献类型：
--
作者：
Davidson JA;Frank BS;Urban TT;Twite M;Jaggers J;Khailova L;Klawitter J
确定心肺转流（CPB）心胸手术后伴或不伴急性肾损伤（阿基）婴儿的循环代谢特征差异。我们对接受CPB的≤ 120 d/o婴儿的术前和术后24 h血清样本进行了二次分析。通过串联质谱法对165种血清代谢物进行靶向分析，对血清样本进行代谢谱分析。然后，我们比较了在术后前72小时内发生或未发生阿基的婴儿，以确定术前和24小时代谢谱的总体差异以及个体代谢物的特定差异。共有57名婴儿被纳入研究。6名婴儿（11%）发生KDIGO 23期阿基，13名（23%）发生1期阿基。术前代谢特征没有区分有与无阿基的婴儿。重度阿基婴儿可通过其24小时代谢特征与无阿基婴儿适度区分，而1期阿基婴儿分为两组，与无阿基或重度阿基组重叠。这些24小时代谢谱中的差异由21种代谢物驱动，这些代谢物在<0.05的经调整的错误发现率下具有显著性。显著改变的途径包括嘌呤、甲硫氨酸和犬尿氨酸/烟酰胺代谢。婴儿心脏手术后中重度阿基与血清代谢组学变化相关，包括嘌呤、蛋氨酸和犬尿氨酸/烟酰胺代谢的显著变化。一部分轻度阿基的婴儿表现出类似的代谢变化，这表明代谢分析在评估低阶段损伤中的潜在作用。
To determine differences in the circulating metabolic profile of infants with or without acute kidney injury (AKI) following cardiothoracic surgery with cardiopulmonary bypass (CPB). We performed a secondary analysis of preoperative and 24hr postoperative serum samples from infants ≤120d/o undergoing CPB. Metabolic profiling of the serum samples was performed by targeted analysis of 165 serum metabolites via tandem mass spectrometry. We then compared infants who did or did not develop AKI in the first 72 hours postoperatively to determine global differences in the preoperative and 24hr metabolic profiles in addition to specific differences in individual metabolites. A total of 57 infants were included in the study. Six infants (11%) developed KDIGO stage 2/3 AKI and 13 (23%) developed stage 1 AKI. The preoperative metabolic profile did not differentiate between infants with versus without AKI. Infants with severe AKI could be moderately distinguished from infants without AKI by their 24hr metabolic profile, while infants with stage 1 AKI segregated into two groups, overlapping with either the no AKI or severe AKI groups. Differences in these 24hr metabolic profiles were driven by 21 metabolites significant at an adjusted false discovery rate of <0.05. Prominently altered pathways include purine, methionine, and kynurenine/nicotinamide metabolism. Moderate-to-severe AKI after infant cardiac surgery is associated with changes in the serum metabolome, including prominent changes to purine, methionine, and kynurenine/nicotinamide metabolism. A portion of infants with mild AKI demonstrated similar metabolic changes, suggesting a potential role for metabolic analysis in the evaluation of lower-stage injury.
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DOI：
10.1016/s2352-4642(17)30069-x
发表时间：
2017-11
期刊：
The Lancet. Child & adolescent health
影响因子：
--
作者：
Jetton JG;Boohaker LJ;Sethi SK;Wazir S;Rohatgi S;Soranno DE;Chishti AS;Woroniecki R;Mammen C;Swanson JR;Sridhar S;Wong CS;Kupferman JC;Griffin RL;Askenazi DJ;Neonatal Kidney Collaborative (NKC)
通讯作者：
Neonatal Kidney Collaborative (NKC)
功能性和管状损伤生物标志物可提高心脏手术后急性肾脏损伤的诊断精度。
影响因子：
24
作者：
Basu, Rajit K.;Wong, Hector R.;Krawczeski, Catherine D.;Wheeler, Derek S.;Manning, Peter B.;Chawla, Lakhmir S.;Devarajan, Prasad;Goldstein, Stuart L.
通讯作者：
Goldstein, Stuart L.
影响因子：
8.8
作者：
Correia GD;Wooi Ng K;Wijeyesekera A;Gala-Peralta S;Williams R;MacCarthy-Morrogh S;Jiménez B;Inwald D;Macrae D;Frost G;Holmes E;Pathan N
通讯作者：
Pathan N
影响因子：
4.6
作者：
Huang H;van Dullemen LFA;Akhtar MZ;Faro ML;Yu Z;Valli A;Dona A;Thézénas ML;Charles PD;Fischer R;Kaisar M;Leuvenink HGD;Ploeg RJ;Kessler BM
通讯作者：
Kessler BM
DOI：
10.1016/j.jtcvs.2011.06.021
发表时间：
2012-02-01
影响因子：
6
作者：
Blinder, Joshua J.;Goldstein, Stuart L.;Jefferies, John L.
通讯作者：
Jefferies, John L.