Serum levels of tumour associated glycoprotein (TAG 72) in patients with gynaecological malignancies.
Serum levels of tumour associated glycoprotein (TAG 72) in patients with gynaecological malignancies.
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DOI：
10.1038/bjc.1990.248
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发表时间：
1990-07
影响因子：
8.8
通讯作者：
Mancuso, S
中科院分区：
文献类型：
--
作者：
Scambia, G;Benedetti Panici, P;Perrone, L;Sonsini, C;Giannelli, S;Gallo, A;Natali, P G;Mancuso, S
在来自良性和恶性妇科疾病患者的726份血清样品中测量TAG 72的血清水平，以评估TAG 72单独或与其他肿瘤标志物组合的临床有用性。66%的卵巢癌患者显示TAG 72抗原浓度异常。在化疗和随访期间，TAG 72系列值与疾病的临床病程之间也存在良好的相关性。在宫颈癌和子宫内膜癌中，TAG 72值异常分别发生在23%和14%的病例中，而乳腺癌患者中没有TAG 72水平异常。在良性疾病患者中，12例良性卵巢肿瘤患者中仅有1例（8%）和15例子宫纤维肌瘤病患者中仅有1例（7%）显示高TAG 72血清水平。然而，TAG 72的测定并没有分别增加卵巢癌和宫颈癌中CA 125和鳞状细胞癌抗原（SCC）的敏感性。对15例具有不同TAG 72基础水平的卵巢癌患者全身给予重组干扰素α-2b并不增加血清抗原水平。
Serum levels of TAG 72 were measured in 726 serum samples from patients with benign and malignant gynaecological conditions in order to evaluate the clinical usefulness of TAG 72 alone or in combination with other tumour markers. Sixty-six per cent of patients with ovarian cancer showed abnormal concentrations of TAG 72 antigen. A good correlation was also found between serial TAG 72 values and the clinical course of disease during chemotherapy and follow-up. In cervical and endometrial cancer abnormal TAG 72 values occurred in 23% and 14% of cases, while none of the patients with breast cancer had abnormal TAG 72 levels. Among patients with benign disease only one out of 12 patients (8%) with benign ovarian tumours and one of 15 patients with uterine fibromyomatosis (7%) showed high TAG 72 serum levels. However, the determination of TAG 72 did not increase the sensitivity of CA 125 and squamous cell carcinoma antigen (SCC), in ovarian and cervical cancer, respectively. The systemic administration of recombinant interferon alpha-2b to 15 patients with ovarian cancer and different basal levels of TAG 72 did not increase serum levels of the antigen.