Circulating high-molecular-weight adiponectin is upregulated in preeclampsia and is related to insulin sensitivity and renal function
Circulating high-molecular-weight adiponectin is upregulated in preeclampsia and is related to insulin sensitivity and renal function
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DOI：
10.1530/eje-07-0454
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发表时间：
2008-02-01
影响因子：
5.8
通讯作者：
Stepan, Holger
中科院分区：
文献类型：
--
作者：
Fasshauer, Mathias;Waldeyer, Theresa;Stepan, Holger
目的：先兆子痫（PE）是妊娠期严重的心血管并发症，与母亲和新生儿未来代谢和心血管风险增加有关。最近，一个矛盾的上调胰岛素增敏和抗动脉粥样硬化脂肪因子脂联素已被证明在PE。此外，高分子量（HMW）脂联素已被建议为生物活性形式的脂肪因子。设计和方法：HMW脂联素和总脂联素血清浓度进行定量ELISA在PE（n=16）患者和妊娠对照妇女没有PE（n=20）。此外，高分子量脂联素和总脂联素相关的临床和生化指标的肾功能，葡萄糖，和脂质代谢，以及inflammation.Results：中位产妇高分子量脂联素和总脂联素水平显着和独立上调几乎两倍PE时，与对照组相比。高分子量脂联素和总脂联素呈正相关，肌酐和负空腹胰岛素在单变量和多变量analysis.Conclusions：我们表明，母亲高分子量脂联素和总脂联素血清浓度显着增加PE和胰岛素敏感性和肾功能不全的标志物呈正相关。脂联素可能是改善PE患者胰岛素敏感性和心血管健康的生理反馈机制的一部分。
Objective: Preeclampsia (PE) is a serious cardiovascular complication in pregnancy which is associated with an increased future metabolic and cardiovascular risk for mother and newborn. Recently, a paradoxical upregulation of the insulin-sensitizing and anti-atherogenic adipokine adiponectin has been shown in PE. Furthermore, high-molecular-weight (HMW) adiponectin has been suggested as the biologically active form of this adipokine.Design and methods: HMW adiponectin and total adiponectin serum concentrations were quantified by ELISA in PE (n=16) patients and pregnant control women without PE (n=20). Furthermore, HMW adiponectin and total adiponectin were correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation.Results: Median maternal HMW adiponectin and total adiponectin levels were significantly and independently upregulated almost twofold in PE when compared with controls. HMW adiponectin and total adiponectin correlated positively with creatinine and negatively with fasting insulin in univariate and multivariate analyses.Conclusions: We show that maternal HMW adiponectin and total adiponectin serum concentrations are significantly increased in PE and are positively associated with markers of insulin sensitivity and renal dysfunction. Adiponectin might be part of a physiological feedback mechanism improving insulin sensitivity and cardiovascular health in PE.