Terpenoids from Salvia trijuga
Terpenoids from Salvia trijuga
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来自 Salvia trijuga 的萜类化合物。
DOI：
10.1021/np100250w
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发表时间：
2010-06-01
影响因子：
5.1
通讯作者：
Zhao, Qin-Shi
中科院分区：
文献类型：
--
作者：
Pan, Zheng-Hong;Wang, Yuan-Yuan;Zhao, Qin-Shi
从丹参中分离到了9个新的双半萜、三jujugins a- i（1-9）、1个新的狼烷三萜、3 α -o -乙酰基-20(29)-狼烯-2 α -醇（10）和24个已知萜类化合物。化合物1的结构经单晶x射线衍射证实。化合物1 ~ 10和32对5种人肿瘤细胞系的细胞毒性进行了评价。化合物9和32对多种细胞系表现出中等毒性作用。
Nine new germacrane sesquiterpenes, trijugins A-I (1-9), a new lupane triterpenoid, 3alpha-O-acetyl-20(29)-lupen-2alpha-ol (10), and 24 known terpenoids were isolated from Salvia trijuga. The structure of compound 1 was confirmed by single-crystal X-ray diffraction. Compounds 1-10 and 32 were evaluated for their cytotoxicity against five human tumor cell lines. Compounds 9 and 32 exhibited moderate toxicity effects against several cell lines.