Truncal Dynamics May Trump: Serial ctDNA to Predict Early Therapeutic Response.
Truncal Dynamics May Trump: Serial ctDNA to Predict Early Therapeutic Response.
复制标题
DOI：
10.1158/1078-0432.ccr-22-2793
复制
发表时间：
2023-01-17
影响因子：
11.5
通讯作者：
Parseghian, Christine M.
中科院分区：
文献类型：
--
作者：
Eluri, Madhulika;Kopetz, Scott;Parseghian, Christine M.
在转移性结直肠癌中使用系列ctDNA既可以改善患者选择，减少化疗毒性，又可以评估可能导致新的治疗策略的新出现的耐药机制，具有广阔的应用前景。然而，在验证其作为治疗反应的预测生物标记物的使用方面，重要的问题仍然存在。
Promising utility of using serial ctDNA in metastatic colorectal cancer to both refine patient selection, reduce toxicity due to chemotherapy, and to evaluate emerging resistance mechanisms that may lead the way to novel therapeutic strategies. However, important questions remain in validating its use as a predictive biomarker of treatment response.