IMMUNOCYTOCHEMICAL EVIDENCE FOR AN AXONAL LOCALIZATION OF GABA IN THE OPTIC NERVES OF RABBITS, RATS, AND CATS
IMMUNOCYTOCHEMICAL EVIDENCE FOR AN AXONAL LOCALIZATION OF GABA IN THE OPTIC NERVES OF RABBITS, RATS, AND CATS
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DOI：
10.1017/s0952523800006787
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发表时间：
1995-11-01
影响因子：
1.9
通讯作者：
POW, DV
中科院分区：
文献类型：
--
作者：
ROGERS, PC;POW, DV
我们通过光学显微镜免疫细胞化学检查了GABA在成年兔、大鼠和猫视神经中的分布。在视神经内，GABA的免疫反应性仅限于轴突的一个小的子集;一些轴突被强烈标记，其他弱标记，而大多数轴突未标记。胶质细胞和其他非神经元的元素总是未标记的。我们的能力，检测GABA在视神经轴突的成年哺乳动物与以前的报告，表明缺乏GABA的免疫反应性，在这样的轴突。我们认为，这种差异可能是由于我们的免疫细胞化学技术，使我们能够检测到低浓度的GABA的敏感性。
We have examined, by light-microscopic immunocytochemistry, the distribution of GABA in the optic nerves of adult rabbits, rats, and cats. Within the optic nerves, immunoreactivity for GABA was restricted to a small subset of axons; some axons were strongly labelled, others weakly labelled, whilst most axons were unlabelled. Glia and other non-neuronal elements were always unlabelled. Our ability to detect GABA in optic nerve axons of adult mammals contrasts with previous reports that indicate a lack of GABA immunoreactivity in such axons. We suggest that this discrepancy may be due to the sensitivity of our immunocytochemical techniques which enable us to detect low concentrations of GABA.