Actinobacteria mediated synthesis of bio-conjugate of carbon dot with enhanced biological activity
Actinobacteria mediated synthesis of bio-conjugate of carbon dot with enhanced biological activity
复制标题
DOI：
10.1007/s13204-020-01392-0
复制
发表时间：
2020-04-18
影响因子：
--
通讯作者：
Thakur, Debajit
中科院分区：
文献类型：
--
作者：
Chowdhury, Devasish;Majumdar, Sristi;Thakur, Debajit
发现抗生素是一项具有挑战性和艰巨的任务。因此，最重要的是努力提高目前可用的抗微生物化合物的效率。在这项工作中，我们已经成功地合成了碳量子点从蜜蜂产生的天然混合物，并结合它们与放线菌的胞外代谢产物。我们首次证明，通过将其与从放线菌合成的碳量子点缀合，可以增强放线菌胞外代谢产物的性质。放线菌-β-碳点偶联物（AEx-pCDs）的微生物活性优于阳性对照利福平。本文还讨论了放线菌-β-碳点偶联物（AEx-pCD）的高效活性机理。
It is a challenging and daunting task of discovering antibiotics. Hence, it is paramount to put efforts in increasing the efficiency of the currently available antimicrobial compounds. In this work, we have successfully synthesized carbon dots from propolis (natural resinous mixture produced by honey bees) and conjugated them with extracellular metabolites of Actinobacteria. We demonstrate for the first time that by conjugating it with carbon dots synthesized from propolis, the properties of extracellular metabolites of Actinobacteria can be enhanced. Actinobacteria-propolis carbon dots conjugate (AEx-pCDs), the microbial activity is better than rifampicin which was taken as a positive control. The mechanistic insight into efficient activity shown by Actinobacteria-propolis carbon dots conjugate (AEx-pCDs) is also discussed.