Recent Progress in Synthesis and Applications of Fluorinated Carbohydrates
Recent Progress in Synthesis and Applications of Fluorinated Carbohydrates
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DOI：
10.2174/138527210791111821
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发表时间：
2010-05-01
影响因子：
2.6
通讯作者：
Guo, Dian-Shun
中科院分区：
文献类型：
--
作者：
Cheng, Yuan;Guo, Ai-Ling;Guo, Dian-Shun
氟化碳水化合物的生物学重要性和活性是迄今为止众多研究的焦点。氟原子的引入可以通过几种方法来实现，如经典的加成法、积木法和自由基加成法。本文简要介绍了近十年来含氟碳水化合物的研究进展。氟化碳水化合物的一般制备方法根据其分子结构中氟原子的类型来组织。本文还讨论了它们的含氮、磷、硫和卤素衍生物及其在生物有机化学中的应用。
The biological importance and activity of fluorinated carbohydrates is a focus of numerous investigations to date. The introduction of fluorine atom(s) can be achieved by a few means such as the classical fluorination, the building block strategy and the radical addition. This is a mini review of carbohydrates containing fluorine atom(s) developed in the past decade. General preparative methods to the fluorinated carbohydrates are organized according to the type of fluorine atom(s) in their molecular structures. The aspects concerning their N-, P-, S- and halogen-containing derivatives and some potential applications in bioorganic chemistry are also discussed.