Poor quality of life and functioning in bipolar disorder.
Poor quality of life and functioning in bipolar disorder.
复制标题
DOI：
10.1186/s40345-017-0078-4
复制
发表时间：
2017-12
影响因子：
4
通讯作者：
Nierenberg AA
中科院分区：
文献类型：
--
作者：
Sylvia LG;Montana RE;Deckersbach T;Thase ME;Tohen M;Reilly-Harrington N;McInnis MG;Kocsis JH;Bowden C;Calabrese J;Gao K;Ketter T;Shelton RC;McElroy SL;Friedman ES;Rabideau DJ;Nierenberg AA
本研究探讨了双相情感障碍患者的人口统计学和临床特征与生活质量和功能的关系。患有 I 型或 II 型双相情感障碍的成年参与者 (N = 482) 参加了 11 个研究中心的比较有效性研究，并完成了医学和精神病史、当前情绪、生活质量和功能的基线测量。症状严重程度至少为轻度抑郁或躁狂/轻躁狂的参与者除了接受为期 6 个月的辅助个性化治疗外，还被随机分配接受锂盐或喹硫平治疗。抑郁和烦躁症状较严重的参与者生活质量较低，功能障碍较高。除物质使用障碍外，所有精神共病均与生活质量较差相关。平均而言，女性的生活质量低于男性。与单身或从未结婚的患者相比，已婚、已婚、离婚或分居的患者的功能障碍更严重。社会劣势的综合评分与较差的功能相关，并且与较差的生活质量略有相关。症状严重程度并不能减轻社会劣势对生活质量或功能的影响。我们的研究结果强调，抑郁、烦躁和精神共病会对双相情感障碍的生活质量和功能产生负面影响。该研究表明，处于社会弱势地位的个人面临功能障碍的风险。 试验注册 本研究已在 ClinicalTrials.gov 注册。识别号：NCT01331304
This study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder. Adult participants (N = 482) with bipolar I or II disorder were enrolled in a comparative effectiveness study across eleven study sites and completed baseline measures of medical and psychiatric history, current mood, quality of life, and functioning. Participants with at least mildly depressive or manic/hypomanic symptomatic severity were randomized to receive lithium or quetiapine in addition to adjunctive personalized treatment for 6 months. Participants with more severe depressive and irritability symptoms had lower quality of life and higher functional impairment. All psychiatric comorbid conditions except substance use disorder were associated with worse quality of life. On average, females had lower quality of life than males. Patients who were married, living as married, divorced, or separated had worse functional impairment compared with patients who were single or never married. A composite score of social disadvantage was associated with worse functioning and marginally associated with worse quality of life. Symptom severity did not moderate the effect of social disadvantage on quality of life or functioning. Our findings highlight that depression, irritability, and psychiatric comorbid conditions negatively impact quality of life and functioning in bipolar disorder. The study suggests that individuals with social disadvantage are at risk for functional impairment. Trial Registration This study is registered with ClinicalTrials.gov. Identification number: NCT01331304