PENICILLAMINE-INDUCED MYASTHENIA-GRAVIS - EFFECTS OF PENICILLAMINE ON ACETYLCHOLINE-RECEPTOR
PENICILLAMINE-INDUCED MYASTHENIA-GRAVIS - EFFECTS OF PENICILLAMINE ON ACETYLCHOLINE-RECEPTOR
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DOI：
10.1212/wnl.32.10.1077
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发表时间：
1982-01-01
期刊：
影响因子：
9.9
通讯作者：
BOCK, E
中科院分区：
文献类型：
--
作者：
BEVER, CT;CHANG, HW;BOCK, E
自身免疫性疾病，包括重症肌无力，发生在接受D-青霉胺治疗的患者中。由于D-青霉胺可能通过抗原改变机制诱导自身抗体，因此研究了D-青霉胺与纯化的加利福尼亚电鳐乙酰胆碱受体的反应。短暂暴露于D-青霉胺导致其共价连接到2个受体亚基，α-青霉胺。(40 000道尔顿）和γ。(59，000道尔顿），推测是通过还原和形成混合二硫化物。D-青霉胺治疗导致纯化的受体和受体丰富的膜片段的平衡乙酰胆碱结合特性的显着修改。
Autoimmune disease, including myasthenia gravis, occur in patients treated with D-penicillamine. Because D-penicillamine might induce autoantibodies by the mechanism of antigenic alteration, the reaction of D-penicillamine with purified acetylcholine receptor from Torpedo californica was studied. Brief exposure to D-penicillamine resulted in its covalent attachment to 2 receptor subunits, .alpha. (40,000 daltons) and .gamma. (59,000 daltons), presumably by reduction and formation of mixed disulfides. D-Penicillamine treatment resulted in a dramatic modification of the equilibrium acetylcholine binding properties of both purified receptor and receptor-rich membrane fragments.