A continuum model of docking of synaptic vesicle to plasma membrane.
A continuum model of docking of synaptic vesicle to plasma membrane.
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突触小泡与质膜对接的连续体模型。
DOI：
10.1098/rsif.2014.1119
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Hui,Chung-Yuen
中科院分区：
文献类型：
--
作者：
Liu,Tianshu;Singh,Pankaj;Jenkins,JamesT;Jagota,Anand;Bykhovskaia,Maria;Hui,Chung-Yuen
神经递质从神经末梢的释放受突触囊泡融合的控制。充满递质的囊泡通过SNARE机制停靠在神经元膜上。在一系列导致融合孔形成的事件之后，神经递质被释放到突触间隙中。在本文中，我们研究的对接过程的力学。一个连续体模型被用来确定一个球形囊泡和质膜的变形，在陷阱机械力和静电斥力的影响下。我们的分析提供了膜中平面应力变化的信息，这是已知的影响融合。此外，提出了一个简单的模型来研究半融合。
Neurotransmitter release from neuronal terminals is governed by synaptic vesicle fusion. Vesicles filled with transmitters are docked at the neuronal membrane by means of the SNARE machinery. After a series of events leading up to the fusion pore formation, neurotransmitters are released into the synaptic cleft. In this paper, we study the mechanics of the docking process. A continuum model is used to determine the deformation of a spherical vesicle and a plasma membrane, under the influence of SNARE-machinery forces and electrostatic repulsion. Our analysis provides information on the variation of in-plane stress in the membranes, which is known to affect fusion. Also, a simple model is proposed to study hemifusion.