Exploring the translational challenge for medical applications of ionising radiation and corresponding radiation protection research.
Exploring the translational challenge for medical applications of ionising radiation and corresponding radiation protection research.
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DOI：
10.1186/s12967-022-03344-4
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发表时间：
2022-03-18
影响因子：
7.4
通讯作者：
McNulty JP
中科院分区：
文献类型：
--
作者：
Bockhold S;Foley SJ;Rainford LA;Corridori R;Eberstein A;Hoeschen C;Konijnenberg MW;Molyneux-Hodgson S;Paulo G;Santos J;McNulty JP
电离辐射的医学应用和相关的辐射防护研究在转化为临床实践时往往遇到长时间的拖延和不一致的执行。需要作出协调一致的努力，分析整个欧洲基于辐射的高质量医疗保健创新转移的研究需求，这可以为制定适合大规模公平实施辐射研究的创新转移框架提供信息。在2021年3月至9月期间，采用德尔菲方法，从一系列专业利益相关者那里就关键的翻译挑战达成共识。共进行了三轮德尔菲调查，采用了一系列由开放式和封闭式问题组成的电子调查。这些调查是通过EURAMED rock -n- roll联盟网络和该领域的著名医学学会传播的。约350名专业人士应邀参加。参与者对每个生成的陈述的同意程度使用6点李克特量表来捕获。共识被定义为中位数≥4，≥60%的应答在量表的上五分位数。此外，评估了各轮反应的稳定性。在第一轮德尔菲中，20人组成的多学科小组产生了127个独特的陈述。第二轮和第三轮德尔菲测试招募了更广泛的130人样本，以评估他们对每个陈述的同意程度，并将其作为关键的翻译挑战。通过迭代德尔菲法得到60条一致意见，其中55条具有较好的稳定性。10个陈述被确定为高优先级挑战，≥80%的陈述评级为“同意”或“非常同意”。系统之间缺乏互操作性、资源不足、教育和培训不理想，以及需要提高公众对电离辐射的益处、风险和应用的认识，这些都被确定为主要的转化挑战。这些发现将有助于为医疗辐射研究提供量身定制的创新转移框架。在线版本包含补充材料，可在10.1186/s12967-022- 033444 -4获得。
Medical applications of ionising radiation and associated radiation protection research often encounter long delays and inconsistent implementation when translated into clinical practice. A coordinated effort is needed to analyse the research needs for innovation transfer in radiation-based high-quality healthcare across Europe which can inform the development of an innovation transfer framework tailored for equitable implementation of radiation research at scale. Between March and September 2021 a Delphi methodology was employed to gain consensus on key translational challenges from a range of professional stakeholders. A total of three Delphi rounds were conducted using a series of electronic surveys comprised of open-ended and closed-type questions. The surveys were disseminated via the EURAMED Rocc-n-Roll consortium network and prominent medical societies in the field. Approximately 350 professionals were invited to participate. Participants’ level of agreement with each generated statement was captured using a 6-point Likert scale. Consensus was defined as median ≥ 4 with ≥ 60% of responses in the upper tertile of the scale. Additionally, the stability of responses across rounds was assessed. In the first Delphi round a multidisciplinary panel of 20 generated 127 unique statements. The second and third Delphi rounds recruited a broader sample of 130 individuals to rate the extent to which they agreed with each statement as a key translational challenge. A total of 60 consensus statements resulted from the iterative Delphi process of which 55 demonstrated good stability. Ten statements were identified as high priority challenges with ≥ 80% of statement ratings either ‘Agree’ or ‘Strongly Agree’. A lack of interoperability between systems, insufficient resources, unsatisfactory education and training, and the need for greater public awareness surrounding the benefits, risks, and applications of ionising radiation were identified as principal translational challenges. These findings will help to inform a tailored innovation transfer framework for medical radiation research. The online version contains supplementary material available at 10.1186/s12967-022-03344-4.
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影响因子：
158.5
作者：
Parker, C.;Nilsson, S.;Sartor, O.
通讯作者：
Sartor, O.
影响因子：
4.4
作者：
Levine, Adam C.;Barry, Meagan A.;Hansoti, Bhakti
通讯作者：
Hansoti, Bhakti
DOI：
10.1177/1539449216687528
发表时间：
2017-04-01
期刊：
OTJR-OCCUPATION PARTICIPATION AND HEALTH
影响因子：
--
作者：
Mackenzie, Lynette;Coppola, Susan;Ledgerd, Richard
通讯作者：
Ledgerd, Richard
影响因子：
168.9
作者：
Fahy, Nick;Hervey, Tamara;McKee, Martin
通讯作者：
McKee, Martin
影响因子：
4
作者：
Gleisner, Katarina Sjogreen;Spezi, Emiliano;Flux, Glenn
通讯作者：
Flux, Glenn