Dual-phase FDG PET/CT for predicting prognosis in operable breast cancer.
Dual-phase FDG PET/CT for predicting prognosis in operable breast cancer.
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DOI：
10.1016/j.breast.2022.07.008
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发表时间：
2022-10
期刊：
影响因子：
3.9
通讯作者：
Okada, Morihito
中科院分区：
文献类型：
--
作者：
Ikejiri, Haruka;Sasada, Shinsuke;Emi, Akiko;Masumoto, Norio;Kadoya, Takayuki;Okada, Morihito
我们的目的是探讨双时相 FDG PET/CT 在预测可手术乳腺癌患者预后中的作用。我们回顾性分析了 998 例接受乳腺癌根治性治疗的患者的数据。治疗前，在 FDG 给药后 1 小时和 2 小时进行 PET/CT 扫描。计算原发肿瘤中两个时间点（SUVmax1和SUVmax2）的最大标准化摄取值（SUVmax）和保留指数（RI）。根据SUVmax1和RI确定PET复发风险（PET-RR），根据代谢参数评估无病生存（DFS）和总生存（OS）。进行倾向评分匹配以调整生物学特征。 SUVmax1 和 RI 的截止值分别为 3% 和 5%。低 PET-RR 组和高 PET-RR 组的 5 年 DFS 分别为 94.9% 和 86.1%（P < 0.001），5 年 OS 分别为 97.6% 和 92.7%（P < 0.001）。在多变量分析中，高T状态、淋巴结转移、三阴性亚型和高PET-RR是DFS差的独立因素。倾向评分匹配显示了类似的结果（5 年 DFS 分别为 91.8% 与 88.6%，P = 0.041，5 年 OS 分别为 97.1% vs. 94.2%，P = 0.240）。双时相 FDG PET/CT 上的 SUVmax1 和 RI 联合参数有助于预测乳腺癌患者的预后。 SUVmax1 高且 FDG 摄取时程为负的患者预后良好。 SUVmax 和 FDG PET/CT 保留指数与乳腺癌预后相关。 SUVmax 高但不随时间增加的乳腺癌预后良好。双时相 FDG PET/CT 可用于预测可手术乳腺癌的预后。
We aimed to investigate the role of dual-phase FDG PET/CT in predicting the prognosis of patients with operable breast cancer. We retrospectively reviewed the data of 998 patients who underwent radical treatment for breast cancer. Before treatment, PET/CT scans were performed 1 and 2 h after FDG administration. The maximum standardized uptake value (SUVmax) at both time points (SUVmax1 and SUVmax2) in the primary tumor and the retention index (RI) were calculated. PET recurrence risk (PET-RR) was determined based on the SUVmax1 and RI, and disease-free survival (DFS) and overall survival (OS) were evaluated according to the metabolic parameters. Propensity score matching was performed to adjust for biological characteristics. The cut-off values for SUVmax1 and RI were 3 and 5%, respectively. The 5-year DFS was 94.9% and 86.1% (P < 0.001), and the 5-year OS was 97.6% and 92.7% (P < 0.001) in the low and high PET-RR groups, respectively. In multivariate analysis, high T status, nodal metastasis, the triple-negative subtype, and high PET-RR were independent factors of poor DFS. Propensity score matching revealed similar findings (5-year DFS 91.8% vs. 88.6%, P = 0.041 and 5-year OS 97.1% vs. 94.2%, P = 0.240, respectively). The combined parameters of SUVmax1 and RI on dual-phase FDG PET/CT were useful for predicting prognosis of patients with breast cancer. Patients with a high SUVmax1 and a negative time course of FDG uptake had a favorable prognosis. SUVmax and retention index on FDG PET/CT are related with breast cancer prognosis. Breast cancer with high SUVmax but no increase over time has a favorable prognosis. Dual-phase FDG PET/CT is useful to predict the prognosis in operable breast cancer.
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影响因子：
1.6
作者：
Hwang JP;Moon JH;Kim HK;Lee MH;Lim CH;Park SB;Yoon JK;Park JM
通讯作者：
Park JM
DOI：
10.1056/nejmoa1804710
发表时间：
2018-07-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sparano JA;Gray RJ;Makower DF;Pritchard KI;Albain KS;Hayes DF;Geyer CE Jr;Dees EC;Goetz MP;Olson JA Jr;Lively T;Badve SS;Saphner TJ;Wagner LI;Whelan TJ;Ellis MJ;Paik S;Wood WC;Ravdin PM;Keane MM;Gomez Moreno HL;Reddy PS;Goggins TF;Mayer IA;Brufsky AM;Toppmeyer DL;Kaklamani VG;Berenberg JL;Abrams J;Sledge GW Jr
通讯作者：
Sledge GW Jr
对医疗统计信息的自由使用的易于使用的软件“ EZR”的调查。
影响因子：
4.8
作者：
Kanda Y
通讯作者：
Kanda Y
影响因子：
3.8
作者：
Aogi, Kenjiro;Kadoya, Takayuki;Sugawara, Yoshifumi;Kiyoto, Sachiko;Shigematsu, Hideo;Masumoto, Norio;Okada, Morihito
通讯作者：
Okada, Morihito
影响因子：
254.7
作者：
Giuliano, Armando E.;Connolly, James L.;Hortobagyi, Gabriel N.
通讯作者：
Hortobagyi, Gabriel N.