Global DNA methylation is influenced by smoking behaviour
Global DNA methylation is influenced by smoking behaviour
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DOI：
10.1016/j.euroneuro.2007.12.005
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发表时间：
2008-04-01
影响因子：
5.6
通讯作者：
Linnebank, Michael
中科院分区：
文献类型：
--
作者：
Hillemacher, Thomas;Frieling, Helge;Linnebank, Michael
表观遗传DNA甲基化水平是人类各种疾病发病机制中的重要因素。由于吸烟可能会影响DNA甲基化，我们研究了吸烟习惯对298个基因组DNA样本(73个父亲，69个母亲和156个子女)全球DNA甲基化的影响。我们没有发现吸烟对全球DNA甲基化的直接影响。然而，子女的DNA甲基化与父亲的DNA甲基化之间存在着强烈的关联，如果两者都从未吸烟(R-corr(2)=0.41，Beta=0.68，p=0.02)，而如果子女吸烟或曾经吸烟，则完全消失。这些发现表明吸烟行为和全球DNA甲基化之间存在关联，这可能对一系列疾病具有重要意义。(C)2008年爱思唯尔和ECNP。版权所有。
The level of epigenetic DNA methylation is an important factor in the pathogenesis of various human diseases. As smoking may influence DNA methylation, we investigated the effect of smoking habits on global DNA methylation in 298 genomic DNA samples (73 fathers, 69 mothers and 156 offspring). We did not find a direct effect of smoking on global DNA methylation. However, there was an association of the offspring's DNA methylation with paternal DNA methylation that was strongest if both had never smoked (R-corr(2) = 0.41, Beta = 0.68, p = 0.02) and completely vanished if the offspring smoked or had ever smoked. These findings suggest an association between smoking behaviour and global DNA methylation, which may be of importance for a wide range of diseases. (c) 2008 Elsevier B.V. and ECNP. All rights reserved.