Ethnic and Geographic Differentiation of Helicobacter pylori within Iran
Ethnic and Geographic Differentiation of Helicobacter pylori within Iran
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DOI：
10.1371/journal.pone.0009645
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发表时间：
2010-03-22
期刊：
影响因子：
3.7
通讯作者：
Falush, Daniel
中科院分区：
文献类型：
--
作者：
Latifi-Navid, Saeid;Ghorashi, Seyed Ali;Falush, Daniel
幽门螺杆菌在人类胃中定植，个体感染持续数十年。这种细菌的传播被证明反映了古代和近代的人类迁徙。我们对H. pylori分离自147名伊朗人，他们在伊朗各地采样，具有良好的地理和种族来源，并将其与来自其他地区的菌株序列进行比较。H.来自伊朗的幽门螺杆菌类似于从欧亚大陆西部分离的其它幽门螺杆菌，并且可以被置于先前描述的Hp欧洲群体中。尽管伊朗位于欧亚大陆的十字路口，但我们没有发现任何证据表明该地区是整个大陆菌株的主要祖先来源。在较小的范围内，我们发现了H。幽门螺杆菌分离自特定的伊朗人口和菌株从土耳其人，乌兹别克人，巴勒斯坦人和以色列人，反映了记录的历史接触在过去两千年。
The bacterium Helicobacter pylori colonizes the human stomach, with individual infections persisting for decades. The spread of the bacterium has been shown to reflect both ancient and recent human migrations. We have sequenced housekeeping genes from H. pylori isolated from 147 Iranians with well-characterized geographical and ethnic origins sampled throughout Iran and compared them with sequences from strains from other locations. H. pylori from Iran are similar to others isolated from Western Eurasia and can be placed in the previously described HpEurope population. Despite the location of Iran at the crossroads of Eurasia, we found no evidence that the region been a major source of ancestry for strains across the continent. On a smaller scale, we found genetic affinities between the H. pylori isolated from particular Iranian populations and strains from Turks, Uzbeks, Palestinians and Israelis, reflecting documented historical contacts over the past two thousand years.