Growth inhibition of intracerebral rat glioma by transfection‐induced human interferon‐β
Growth inhibition of intracerebral rat glioma by transfection‐induced human interferon‐β
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转染诱导的人干扰素-β对大鼠脑内胶质瘤生长的抑制作用
DOI：
10.1002/jso.2930590207
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发表时间：
1995
影响因子：
2.5
通讯作者：
T. Uozumi
中科院分区：
文献类型：
--
作者：
K. Harada;J. Yoshida;M. Mizuno;K. Kurisu;T. Uozumi
在我们先前的脂质体介导的人干扰素-β基因转染人胶质瘤裸鼠皮下移植瘤的研究中，我们发现人干扰素-β基因是由肿瘤细胞产生和分泌的，实体瘤的生长被完全抑制。本研究观察了携带人干扰素-β基因的脂质体(pSV2IFN-β)对T9大鼠脑内移植瘤的生长抑制作用。同时将肿瘤细胞和含有pSV2IFN-β或其他添加剂的脂质体注射到大鼠脑内。在注射脂质体的大鼠脑内生长的实体胶质瘤中检测到人干扰素-β，核磁共振成像显示肿瘤生长受到抑制。此外，用含有pSV2IFN-β的脂质体治疗的大鼠出现神经症状的潜伏期显著延长。但治疗组大鼠存活时间未见明显延长。©1995 Wiley-Liss公司
In our previous study on liposome‐mediated transfection of the human interferon‐β (HuIFN‐β) gene into subcutaneously implanted human gliomas in nude mice, we found that HuIFN‐β was produced and secreted by the tumor cells and that the growth of solid tumors was completely inhibited. The present study investigated the growth‐inhibitory effect of liposomes containing the HuIFN‐β gene inserted into a vector (PSV2IFN‐β) on T9 rat glioma implanted into the brains of rats. Tumor cells and liposomes containing pSV2IFN‐β or other additives were simultaneously injected into the brains of rats. HuIFN‐β was detected in solid gliomas growing in the brains of rats injected with liposomes and magnetic resonance imaging (MRI) showed that tumor growth was inhibited. In addition, the latent period until the appearance of neurological symptoms was significantly prologed in rats treated with liposomes containing pSV2IFN‐β. However, the survival time of the treated rats was not significantly increased. © 1995 Wiley‐Liss, Inc.
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影响因子：
56.9
作者：
HUANG, HJS;YEE, JK;LEE, WH
通讯作者：
LEE, WH
用环磷酰胺和长春新碱治疗复发性神经胶质瘤患者。
影响因子：
4.1
作者：
Longee,DC;Friedman,HS;AlbrightJr,RE;Burger,PC;Oakes,WJ;Moore,JO;ScholdJr,SC
通讯作者：
ScholdJr,SC
影响因子：
4.1
作者：
SHAPIRO, WR;GREEN, SB;MAHALEY, MS
通讯作者：
MAHALEY, MS
影响因子：
4.1
作者：
BREM, H;MAHALEY, S;KENEALY, JN
通讯作者：
KENEALY, JN