CircRNA: functions and properties of a novel potential biomarker for cancer.
CircRNA: functions and properties of a novel potential biomarker for cancer.
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DOI：
10.1186/s12943-017-0663-2
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发表时间：
2017-05-23
期刊：
影响因子：
37.3
通讯作者：
Wu M
中科院分区：
文献类型：
--
作者：
Meng S;Zhou H;Feng Z;Xu Z;Tang Y;Li P;Wu M
环状rna是一类新型的内源性非编码rna，其特点是其共价闭环结构没有5 ‘帽或3 ’ Poly a尾部。尽管环状rna的产生和功能机制尚不完全清楚，但最近的研究表明，环状rna可能作为疾病诊断和治疗的潜在分子标志物，在人类疾病，特别是肿瘤的发生和发展中发挥重要作用。本文综述了环状rna的分类、生物发生、分子水平上的功能、性质以及环状rna作为肿瘤生物标志物的可能性。
Circular RNAs, a novel class of endogenous noncoding RNAs, are characterized by their covalently closed loop structures without a 5′ cap or a 3′ Poly A tail. Although the mechanisms of circular RNAs’ generation and function are not fully clear, recent research has shown that circular RNAs may function as potential molecular markers for disease diagnosis and treatment and play an important role in the initiation and progression of human diseases, especially in tumours. This review summarizes some information about categories, biogenesis, functions at the molecular level, properties of circular RNAs and the possibility of circular RNAs as biomarkers in cancers.