The natural history of chronic renal failure:: Results from an unselected, population-based, inception cohort in Sweden
The natural history of chronic renal failure:: Results from an unselected, population-based, inception cohort in Sweden
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DOI：
10.1053/j.ajkd.2005.07.040
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发表时间：
2005-11-01
影响因子：
13.2
通讯作者：
Fored, CM
中科院分区：
文献类型：
--
作者：
Evans, M;Fryzek, JP;Fored, CM
背景慢性肾功能衰竭(CRF)患者在开始肾脏替代治疗(RRT)前后的死亡率都很高。然而，在未选择的慢性肾功能衰竭人群中，很少有关于死亡率和进展的研究。方法：我们对920名年龄在18-74岁的男性和女性进行了为期55-79个月的以人群为基础的初始队列随访。采用Cox回归模型探讨研究中的独立变量(年龄、性别、原发肾脏疾病、体重指数[BMI]和入院时肾小球滤过率[GFR])与预后(死亡和RRT开始)之间的关系。结果：739例患者(80%)在随访期内开始接受放射治疗。正如预期的那样，入院时的肾小球滤过率与RRT的发生率明显相关(P<；0.0001)。年龄与RRT发生率呈负相关(患者调整后的相对风险=65岁相对于患者
Background Mortality rates in patients with chronic renal failure (CRF) are high both before and after start of renal replacement therapy (RRT). However, few studies of mortality and progression have been performed in an unselected CRF population. Methods: We followed up a population-based inception cohort of 920 men and women aged 18 to 74 years who had CRF (serum creatinine level > 3.4 mg/dL [>300 mu mol/L] for men and >2.8 mg/dL [>250 mu mol/L] for women) for 55 to 79 months. Relationships between the outcomes (death and start of RRT) and independent variables under study (age, sex, primary renal disease, body mass index [BMI], and glomerular filtration rate [GFR] at entry) were explored by using Cox regression models. Results: Seven hundred thirty-nine patients (80%) started RRT during the follow-up period. As expected, GFR at entry was clearly linked to the incidence of RRT (P < 0.0001). Age was related inversely to incidence of RRT (adjusted relative risk for patients >= 65 years relative to patients