The Modified Graeb Score: an enhanced tool for intraventricular hemorrhage measurement and prediction of functional outcome.
The Modified Graeb Score: an enhanced tool for intraventricular hemorrhage measurement and prediction of functional outcome.
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DOI：
10.1161/strokeaha.112.670653
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发表时间：
2013-03
期刊：
影响因子：
8.3
通讯作者：
CLEAR and VISTA Investigators
中科院分区：
文献类型：
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作者：
Morgan TC;Dawson J;Spengler D;Lees KR;Aldrich C;Mishra NK;Lane K;Quinn TJ;Diener-West M;Weir CJ;Higgins P;Rafferty M;Kinsley K;Ziai W;Awad I;Walters MR;Hanley D;CLEAR and VISTA Investigators
缺乏简单快速的脑室内出血（IVH）体积测量方法。我们开发并验证了对原始Graeb量表的修改，以促进随着时间的推移对IVH的快速评估。我们使用来自凝块溶解：评价rtPA B（CLEAR B）加速出血消退研究的数据，探讨了改良Graeb量表（mGS）、原始Graeb量表、测量的IVH体积和结局之间的关系。我们还研究了它的可靠性。然后，我们使用虚拟国际卒中试验档案（VISTA）中包含的数据，评估了大样本IVH参与者中mGS与结局之间的关系。我们使用改良的兰金量表（>3分表示预后差）定义预后。CLEAR B研究包括36名受试者的360次扫描。mGS评分与IVH体积高度相关（R = 0.80，P<0.0001，R0.65）。基线mGS可预测不良结局（接受手术特征曲线下面积0.74，95%置信区间0.57-0.91），而原始Graeb量表则不能预测不良结局。VISTA研究包括399名参与者。mGS每增加一个单位，导致不良结局的比值增加12%（比值比，1.12; 95%置信区间，1.05-1.19）。两项研究的信度（内部和interreader）都很好。mGS是一种用于IVH体积测量的半定量量表，是一种具有预后有效性的可靠测量方法，适合在临床实践和研究中快速使用。
Simple and rapid measures of intraventricular hemorrhage (IVH) volume are lacking. We developed and validated a modification of the original Graeb scale to facilitate rapid assessment of IVH over time. We explored the relationship between the modified Graeb scale (mGS), original Graeb scale, measured IVH volume, and outcome using data from the Clot Lysis: Evaluating Accelerated Resolution of Hemorrhage with rtPA B (CLEAR B) study. We also explored its reliability. We then evaluated the relationship between mGS and outcome in a large sample of participants with IVH using data contained within the Virtual International Stroke Trials Archive (VISTA). We defined outcome using the modified Rankin scale (>3 signifying poor outcome). The CLEAR B study included 360 scans from 36 subjects. The mGS score and IVH volume were highly correlated (R = 0.80, P<0.0001, R 0.65). Baseline mGS was predictive of poor outcome (area under receiving operating characteristic curve 0.74, 95% confidence interval, 0.57–0.91), whereas the original Graeb scale was not. The VISTA study included 399 participants. Each unit increase in the mGS led to a 12% increase in the odds of a poor outcome (odds ratio, 1.12; 95% confidence interval, 1.05–1.19). Measures of reliability (intra- and interreader) were good in both studies. The mGS, a semiquantitative scale for IVH volume measurement, is a reliable measure with prognostic validity suitable for rapid use in clinical practice and in research.