The impact of ageing and sex on the association between sleepiness and sleep disordered breathing.
The impact of ageing and sex on the association between sleepiness and sleep disordered breathing.
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DOI：
10.1183/09031936.00177411
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Peppard PE
中科院分区：
文献类型：
--
作者：
Morrell MJ;Finn L;McMillan A;Peppard PE
调查与睡眠呼吸障碍 (SDB) 相关的嗜睡症状与年龄相关的变化。威斯康星州睡眠队列参与者接受了多导睡眠图、Epworth 嗜睡量表 (ESS) 和多次睡眠潜伏期测试 (MSLT) 的评估。 SDB定义为呼吸暂停/呼吸不足指数≥15次/小时，嗜睡定义为ESS≥10且MSLT≤5分钟。使用将嗜睡与 SDB 相关联的广义估计方程以及检查纵向嗜睡状态变化的条件逻辑回归（仅 ESS）计算优势比。模型先验地按性别分层。在多个时间点测量了 1281 名参与者的 ESS 和 998 名参与者的 MSLT（ESS n=3695；MSLT n=1846）。在男性中，SDB 与年龄之间存在显着的交互作用，但在女性中则不然。与没有 SDB 的男性相比，患有 SDB 的 40 岁男性的嗜睡模型比值比 (OR) 显着（OR：ESS 2.1；MSLT 2.9）；然而，这些关联在 60 岁时并不显着。受试者内嗜睡的比值比在 40 岁时也很显着（OR：3.4），但在 60 岁时则不显着。由于嗜睡经常被用作治疗标志物，因此嗜睡与 SDB 之间的关联性随年龄而降低可能对老年人 SDB 的诊断和治疗具有临床意义。
To investigate age-related changes in sleepiness symptoms associated with sleep disordered breathing (SDB). Wisconsin Sleep Cohort participants were assessed with polysomnography, Epworth Sleepiness Scale (ESS) and Multiple Sleep Latency Test (MSLT). SDB was defined as an apnea/hypopnea index≥15 events/hour, sleepiness as ESS≥10 and MSLT≤5 minutes. Odds ratios were calculated using generalized estimating equations associating sleepiness with SDB, and conditional logistic regression examining changes in longitudinal sleepiness status (ESS only). Models were, a priori, stratified by gender. ESS was measured in 1281 participants and MSLT in 998, at multiple time points (ESS n=3695; MSLT n=1846). Significant interactions were found between SDB and age in men, but not women. The odds ratios (OR) modeled for sleepiness in a 40 year old male with SDB were significant, compared to a male without SDB (OR: ESS 2.1; MSLT 2.9); however, these associations were not significant at 60 years. The within-subject odds ratio for sleepiness was also significant at 40 years (OR: 3.4), but not at 60 years. The age-related reductions in the association between sleepiness and SDB may have clinical implications for the diagnosis and treatment of SDB in older people since sleepiness is often used as a therapeutic marker.
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影响因子：
8.3
作者：
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通讯作者：
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8.3
作者：
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通讯作者：
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