Aspects of neuroticism and the amygdala Chronic tuning from motivational styles
Aspects of neuroticism and the amygdala Chronic tuning from motivational styles
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DOI：
10.1016/j.neuropsychologia.2010.06.026
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发表时间：
2010-10-01
期刊：
影响因子：
2.6
通讯作者：
Abduljalil, Amir M.
中科院分区：
文献类型：
--
作者：
Cunningham, William A.;Arbuckle, Nathan L.;Abduljalil, Amir M.
最近的研究和理论强调了杏仁核激活的动态本质，而不是简单地对一些有限的刺激类别敏感。在这项研究中，杏仁核的激活似乎依赖于接受者的目标。在这项研究中，我们扩展了这一工作，证明了一个人寻求实现目标的方式也调节了杏仁核的反应。具体地说，我们检查了神经质(波动/戒断)方面的调制效应，神经质是一个人格变量，与广泛性焦虑和杏仁核敏感性的差异有关，而神经质波动被认为与战斗-逃跑-冻结系统(Fff)和任何敏感性有关。负性提示神经质-戒断被认为与行为抑制系统(BIS)和被动回避的普遍倾向有关，在功能磁共振成像扫描期间，参与者被呈现积极的负面和中性的图像，并被要求在不同的试验块中接近(感知上更近)或避免(感知更远)刺激，这与提出神经质这两个方面之间分离的假设相一致--波动性较高的神经质参与者增加了对负面刺激的杏仁核激活(无论他们是否被接近或回避)，而较高神经质-撤退的参与者对所有接近的刺激的杏仁核激活(无论刺激价如何)这些数据进一步支持杏仁核功能的激励性显著假设，并证明目标追求的目的和手段对于形成反应都很重要(C)2010爱思唯尔有限公司版权所有
Recent research and theory has highlighted the dynamic nature of amygdala activation Rather than simply being sensitive to a few limited stimulus categories amygdala activation appears to be dependent on the goals of the perceiver In this study we extend this line of work by demonstrating that the means by which a person seeks to accomplish a goal also modulates the amygdala response Specifically we examine the modulatory effects of the aspects of neuroticism (volatility/withdrawal) a personality variable that has been linked to both generalized anxiety and differences in amygdala sensitivity Whereas Neurotiosm-Volatility is proposed to be associated with the fight-flight-freeze system (FFFS) and a sensitivity for any cues of negativity Neuroticism-Withdrawal is proposed to be associated with the behavioral inhibition system (BIS) and a generalized tendency toward passive avoidance During fMRI scanning participants were presented with positive negative and neutral Images and were required to approach (move perceptually closer) or avoid (move perceptually farther away) stimuli in different blocks of trials Consistent with hypotheses proposing a dissociation between these two aspects of neuroticism participants higher in Neuroticism-Volatility had Increased amygdala activation to negative stimuli (regardless of whether they were approached or avoided) whereas participants higher in Neuroticism-Withdrawal had increased amygdala activation to all approached stimuli (regardless of stimulus valence) These data provide further support for the motivational salience hypothesis of amygdala function and demonstrate that both the ends and means of goal pursuit are important for shaping a response (C) 2010 Elsevier Ltd All rights reserved