Individual and Joint Prevalence of Three Nonmotor Symptoms of PD in the US General Population
Individual and Joint Prevalence of Three Nonmotor Symptoms of PD in the US General Population
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DOI：
10.1002/mds.25950
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发表时间：
2014-09-01
影响因子：
8.6
通讯作者：
Peddada, Shyamal
中科院分区：
文献类型：
--
作者：
Chen, Honglei;Huang, Xuemei;Peddada, Shyamal
背景：一些非运动症状可能早于帕金森病 (PD) 的临床诊断数年。方法：我们检查了 2005-2008 年美国国家健康和营养检查调查的 10,477 名参与者中抑郁、白天嗜睡和不频繁排便的个体和联合患病率。结果：对于所有症状，女性的患病率高于男性。重要的是，很少有参与者有两种或多种症状：男性中，20至29岁为1.3%，30至39岁为1.0%，40至49岁为1.2%，50至59岁为3.5%，60至69岁为1.7%，70至79岁为1.1%，80岁或以上为1.2%； the corresponding prevalence in women was 3.1%, 5.2%, 5.7%, 4.1%, 3.1%, 2.3%, and 1.2%, respectively.在男性和女性中，抑郁症与排便次数少和白天嗜睡相关，但后两者是相互独立的。结论：多种非运动症状的存在在一般人群中并不常见，并且女性的患病率高于男性。 (C) 2014 International Parkinson and Movement Disorder Society
Background: Some nonmotor symptoms may precede the clinical diagnosis of Parkinson's disease (PD) by years.Methods: We examined the individual and joint prevalence of depression, daytime sleepiness, and infrequent bowel movement among 10,477 participants of the US National Health and Nutrition Examination Surveys 2005-2008.Results: For all symptoms, the prevalence was higher in women than in men. Importantly, few participants had two or more symptoms: 1.3% at ages 20 to 29, 1.0% at 30 to 39, 1.2% at 40 to 49, 3.5% at 50 to 59, 1.7% at 60 to 69, 1.1% at 70 to 79, and 1.2% at ages 80 years or older in men; the corresponding prevalence in women was 3.1%, 5.2%, 5.7%, 4.1%, 3.1%, 2.3%, and 1.2%, respectively. In both men and women, depression was correlated with infrequent bowel movement and daytime sleepiness, but the latter two were mutually independent.Conclusion: The presence of multiple nonmotor symptoms was uncommon in the general population and the prevalence was higher in women than in men. (C) 2014 International Parkinson and Movement Disorder Society