EXPERIMENTAL-MODELS TO PROMOTE HEALING OF TEARS IN THE AVASCULAR SEGMENT OF CANINE KNEE MENISCI
EXPERIMENTAL-MODELS TO PROMOTE HEALING OF TEARS IN THE AVASCULAR SEGMENT OF CANINE KNEE MENISCI
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DOI：
10.2106/00004623-198971090-00013
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发表时间：
1989-10-01
影响因子：
5.3
通讯作者：
AKESON, WH
中科院分区：
文献类型：
--
作者：
GERSHUNI, DH;SKYHAR, MJ;AKESON, WH
在犬外侧半月板中产生纵向撕裂，并应用技术通过从半月板周边到撕裂处去除组织核心或通过在撕裂处植入血管化滑膜瓣来诱导愈合。未固定的膝关节中的半月板撕裂无法愈合，固定在石膏中但承受一定重量的膝关节中的半月板撕裂愈合不良且零星。然而，当膝关节被牢固固定，并通过使用外部骨骼固定器横跨关节8至12周来防止负重时，通过核心去除或滑膜瓣技术治疗的撕裂愈合率更高。新血管形成和获得修复细胞的来源似乎在愈合过程中很重要。临床相关性：目前治疗半月板无血管区撕裂的常用方法包括一定程度的半月板切除，这可能会产生相当大的发病率。因此，有必要开发技术，以诱导愈合的尿道撕裂，同时保持尿道结构。
Longitudinal tears were created in canine lateral menisci and techniques were applied to induce healing by removal of a core of tissue from the periphery of the meniscus to the tear or by implantation of a vascularized synovial flap in to the tear. The meniscal tears did not heal in knees that were not immobilized, and they healed poorly and sporadically in knees that were immobilized in a cast but bore some weight. However, a higher percentage of tears that were treated by the core-removal or synovial-flap technique healed when the knee was firmly immobilized and weight-bearing was prevented by the use of an external skeletal fixator across the joint for eight to twelve weeks. Neovascularization and access to a source of reparative cells appear to be important in the healing process. Clinical relevance: Currently favored methods of treating tears in the avascular region of the meniscus involve some degree of meniscal excision, which may produce considerable morbidity. The development of techniques to induce the healing of meniscal tears, while preserving meniscal architecture, is thus warranted.