Effect of ethnicity on the hypnotic and cardiovascular characteristics of propofol induction
Effect of ethnicity on the hypnotic and cardiovascular characteristics of propofol induction
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DOI：
10.1111/j.1365-2044.2010.06568.x
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发表时间：
2011-01-01
期刊：
影响因子：
10.7
通讯作者：
Morley, A. P.
中科院分区：
文献类型：
--
作者：
Natarajan, A.;Strandvik, G. F.;Morley, A. P.
我们比较了50例白色和50例黑人患者（年龄18-65岁）中导致言语反应丧失和脑电双频指数抑制的丙泊酚剂量。丙泊酚在40 mg.kg（-1）.h（-1）时给药，当脑电双频指数降至50时，丙泊酚剂量降至8 mg. kg（-1）.h（-1）。我们总共记录了15分钟的心率和平均动脉压，并计算了这段时间内每种心率和平均动脉压相对于基线的最大百分比变化。一位统计学家对患者种族不知情，发现白色和黑人患者语言反应丧失的平均（SD）丙泊酚剂量分别为1.41（0.37）mg.kg（-1）和1.16（0.25）mg. kg（-1）（p < 0.001）。心率最大百分比变化的相应数值分别为14.1（12.6）%和7.5（14.0）%（p = 0.015）。其他差异不显著。黑人患者丧失言语反应所需的丙泊酚剂量低于白色患者，但将脑电双频指数抑制至50所需的丙泊酚剂量不低于白人患者。
We compared the propofol dose causing loss of verbal response and suppression of bispectral index to 50, between 50 white and 50 black patients, aged 18-65 years. Propofol was administered at 40 mg.kg(-1).h(-1) and reduced to 8 mg.kg(-1).h(-1) when bispectral index fell to 50. We recorded heart rate and mean arterial pressure for 15 min in total and calculated, for this period, maximal percentage change from baseline for each. A statistician, blinded to patient ethnicity, found mean (SD) propofol dose for loss of verbal response in white and black patients to be 1.41 (0.37) mg.kg(-1) and 1.16 (0.25) mg.kg(-1), respectively (p < 0.001). Corresponding figures for maximal percentage change in heart rate were 14.1 (12.6) % and 7.5 (14.0) % (p = 0.015). Other differences were non-significant. The dose of propofol required for loss of verbal response, but not for suppression of bispectral index to 50, is lower in black than in white patients.