Are statins beneficial for the treatment of pulmonary hypertension?
Are statins beneficial for the treatment of pulmonary hypertension?
复制标题
他汀类药物对治疗肺动脉高压有效吗
DOI：
10.1016/j.cdtm.2017.10.001
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发表时间：
2017-12
影响因子：
--
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Wang L;Yang T;Wang C
肺动脉高压（PH）是一种以血管收缩和血管重塑为特征的疾病，预后不良。目前可用的医学治疗是支持性护理治疗和肺血管靶向治疗。PH的靶向治疗包括前列环素类似物、内皮素受体拮抗剂和5型磷酸二酯酶抑制剂;然而，这些治疗不能逆转肺血管重塑。最近，出现了许多涉及他汀类药物的新型治疗选择。在这篇综述中，我们试图总结他汀类药物在PH治疗中的作用及其潜在的临床效果的现有知识。许多基础研究已经证明，他汀类药物在体外和实验模型中均有助于PH的治疗。他汀类药物作用的主要机制是恢复内皮功能、减弱肺血管重塑、调节基因表达、调节PH相关的细胞内信号传导过程、抗炎反应以及与其他靶向药物的协同作用。然而，PH的临床研究，特别是随机对照试验很少。目前的临床研究显示，他汀类药物治疗PH的临床效果存在差异，需要精心设计的随机对照试验来验证他汀类药物治疗PH的安全性和有效性。
Pulmonary hypertension (PH) is a condition characterized by vasoconstriction and vascular remodeling with a poor prognosis. The current medical treatments available are supportive care therapy and pulmonary vascular-targeted therapy. Targeted treatments for PH include prostacyclin analogs, endothelin receptor antagonists, and phosphodiesterase type 5 inhibitors; however, these treatments cannot reverse pulmonary vascular remodeling. Recently, many novel treatment options involving drugs such as statins have been emerging. In this review, we attempt to summarize the current knowledge of the role of statins in PH treatment and their potential clinical effects. Many basic researches have proved that statins can be helpful for the treatment of PH both in vitro and in experimental models. The main mechanisms underlying the effects of statins are restoration of endothelial function, attenuation of pulmonary vascular remodeling, regulation of gene expression, regulation of intracellular signaling processes involved in PH, anti-inflammatory responses, and synergy with other targeted drugs. Nevertheless, clinical researches, especially randomized controlled trials for PH are rare. The current clinical researches show contrasting results on the clinical effects of statins in patients with PH. Carefully designed randomized, controlled trials are needed to test the safety and efficacy of statins for PH treatment.
影响因子：
2.6
作者：
Kuang T;Wang J;Zeifman A;Pang B;Huang X;Burg ED;Yuan JX;Wang C
通讯作者：
Wang C