High resolution imaging of normal and osteoarthritic cartilage with optical coherence tomography.
High resolution imaging of normal and osteoarthritic cartilage with optical coherence tomography.
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发表时间：
1999-03
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通讯作者：
J. Herrmann;C. Pitris;B. Bouma;S. Boppart;C. Jesser;D. Stamper;J. Fujimoto;M. Brezinski
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作者：
J. Herrmann;C. Pitris;B. Bouma;S. Boppart;C. Jesser;D. Stamper;J. Fujimoto;M. Brezinski
目的利用光学相干断层扫描技术（OCT）对骨关节炎关节软骨的显微结构进行研究。OCT类似于超声波，测量反向反射的红外光而不是声波的强度。方法对20例正常和骨关节炎软骨标本的100多个部位进行OCT成像。结果：显微结构包括原纤维化、纤维化、软骨厚度和新骨生长，分辨率在5 - 15 μ m之间。此外，偏振成像的灵敏度表明偏振光谱的诊断作用。结论OCT是一种有吸引力的关节内成像新技术，因为它的分辨率高（高于任何现有的临床技术），能够集成到小型关节镜，紧凑的便携式设计，以及相对较低的成本。
OBJECTIVE We describe optical coherence tomography (OCT), a high resolution micron scale imaging technology, for assessment of osteoarthritic articular cartilage microstructure. OCT is analogous to ultrasound, measuring the intensity of backreflected infrared light rather than acoustical waves. METHODS OCT imaging was performed on over 100 sites on 20 normal and osteoarthritic cartilage specimens in vitro. RESULTS Microstructures that were identified included fibrillations, fibrosis, cartilage thickness, and new bone growth at resolutions between 5 and 15 microm. In addition, the polarization sensitivity of imaging suggested a diagnostic role of polarization spectroscopy. CONCLUSION OCT represents an attractive new technology for intraarticular imaging due to its high resolution (greater than any available clinical technology), ability to be integrated into small arthroscopes, compact portable design, and relatively low cost.