FUNCTIONAL-PROPERTIES OF NONMUSCLE TROPOMYOSIN ISOFORMS
FUNCTIONAL-PROPERTIES OF NONMUSCLE TROPOMYOSIN ISOFORMS
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DOI：
10.1016/0955-0674(94)90122-8
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发表时间：
1994-02-01
影响因子：
7.5
通讯作者：
HELFMAN, DM
中科院分区：
文献类型：
--
作者：
PITTENGER, MF;KAZZAZ, JA;HELFMAN, DM
原肌球蛋白是肌动蛋白微丝结合蛋白家族。在许多生物体中都发现了它们，包括酵母、线虫、果蝇、鸟类和哺乳动物。在后生动物中，不同形式的原肌球蛋白是特定细胞类型的特征。大多数非肌肉细胞，如成纤维细胞，表达五到八种亚型的原肌球蛋白。不同的异构体表现出不同的生化特性，似乎是特定细胞功能所必需的。
Tropomyosins are a family of actin filament binding proteins. They have been identified in many organisms, including yeast, nematodes, Drosophila, birds and mammals. In metazoans, different forms of tropomyosin are characteristic of specific cell types. Most non-muscle cells, such as fibroblasts, express five to eight isoforms of tropomyosins. The various isoforms exhibit distinct biochemical properties that appear to be required for specific cellular functions.