Neuropeptidergic Control of an Internal Brain State Produced by Prolonged Social Isolation Stress.
Neuropeptidergic Control of an Internal Brain State Produced by Prolonged Social Isolation Stress.
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长期社会孤立压力产生的内部大脑状态的神经肽能控制。
DOI：
10.1101/sqb.2018.83.038109
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Anderson,DavidJ
中科院分区：
文献类型：
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作者：
Zelikowsky,Moriel;Ding,Keke;Anderson,DavidJ
长时间的社会孤立会产生一种内部状态，对大脑和行为产生深远的影响。然而，长期社会隔离的神经生物学基础一直相对不足。在这里，我们回顾了最近的文献暗示肽类神经调质在建立和维持这种内部状态。更具体地说，我们描述了一个进化保守的作用，神经肽速激肽在社会隔离诱导的侵略控制和审查最近的数据，阐明了Tac2控制的方式，社会隔离对行为的广泛影响在小鼠。最后，我们讨论了额外的神经调质在控制社会隔离和更普遍的作用，Tac2在其他形式的压力的反应中的潜在作用。
Prolonged periods of social isolation can generate an internal state that exerts profound effects on the brain and behavior. However, the neurobiological underpinnings of protracted social isolation have been relatively understudied. Here, we review recent literature implicating peptide neuromodulators in the establishment and maintenance of such internal states. More specifically, we describe an evolutionarily conserved role for the neuropeptide tachykinin in the control of social isolation–induced aggression and review recent data that elucidate the manner by which Tac2 controls the widespread effects of social isolation on behavior in mice. Last, we discuss potential roles for additional neuromodulators in controlling social isolation and a more general role for Tac2 in the response to other forms of stress.