DIURNAL-VARIATION OF CEREBRAL BLOOD-FLOW IN RAT HIPPOCAMPUS
DIURNAL-VARIATION OF CEREBRAL BLOOD-FLOW IN RAT HIPPOCAMPUS
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DOI：
10.1161/01.str.21.10.1464
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发表时间：
1990-10-01
期刊：
影响因子：
8.3
通讯作者：
KIMURA, F
中科院分区：
文献类型：
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作者：
ENDO, Y;JINNAI, K;KIMURA, F
我们在10只未麻醉的自由活动大鼠中测量了24小时内的局部脑血流量，以确定海马中的血流量是否随一天中的时间而波动。我们测量氢清除率在1小时的时间间隔使用聚乙烯涂层的铂电极与1毫米裸露的尖端植入背海马。个体大鼠在一天内显示出广泛的局部脑血流量值（从30至100 ml/min/100 g组织）。在10只大鼠中的7只中，黑暗周期（7 PM-5 AM）的总体平均海马血流量显著（p < 0.001，0.01或0.05）大于光照周期（6 AM-6 PM），显示平均增加20%。此外，在所有10只大鼠中，11 PM时的最大平均海马血流量比中午时的最小值大42%。我们的研究首次表明，在海马局部脑血流量显示昼夜变化。
We measured local cerebral blood flow over 24 hours in 10 unanesthetized, freely moving rats to determine whether blood flow in the hippocampus fluctuated as a function of time of day. We measured hydrogen clearance at 1-hour intervals using a polyurethane-coated platinum electrode with a 1-mm bare tip implanted in the dorsal hippocampus. Individual rats displayed a wide range of local cerebral blood flow values (from 30 to 100 ml/min/100 g tissue) in a day. In seven of the 10 rats, the overall mean hippocampal blood flow for the dark cycle (7 PM-5 AM) was significantly (p < 0.001, 0.01, or 0.05) greater than that for the light cycle (6 AM-6 PM), showing an average increase of 20%. Further, the maximum mean hippocampal blood flow at 11 PM in all 10 rats was 42% greater than the minimum at noon. Our study demonstrates for the first time that local cerebral blood flow in the hippocampus shows diurnal variation.