Interaction of calcitonin and calcitonin gene-related peptide at receptor sites in target tissues.
Interaction of calcitonin and calcitonin gene-related peptide at receptor sites in target tissues.
复制标题
降钙素和降钙素基因相关肽在靶组织受体位点的相互作用。
作者：
D. Goltzman;J. Mitchell
在神经系统和外周组织中发现了离散的降钙素（CT）和降钙素基因相关肽（CGRP）受体位点。每个肽都能与另一个肽的特定受体发生交叉反应。与CT受体相比，CGRP受体不与腺苷酸环化酶相连。而CGRP通过与CT受体相互作用，明显刺激CT靶组织腺苷酸环化酶。CGRP和哺乳动物CT抑制CT结合的相对能力提示CGRP可能是中枢神经系统CT受体的内源性配体。
Discrete receptor sites for calcitonin (CT) and calcitonin gene-related peptide (CGRP) were found in the nervous system and in peripheral tissues. Each peptide was capable of cross-reacting with the specific receptor of the other. In contrast to CT receptors, CGRP receptors were not linked to adenylate cyclase. However, CGRP could stimulate adenylate cyclase in CT target tissues apparently by interacting with CT receptors. The relative abilities of CGRP and mammalian CT to inhibit CT binding suggest that CGRP could serve as an endogenous ligand for CT receptors in the central nervous system.
大鼠血源性降钙素的脑受体：遗传性尿崩症的室周定位和抗利尿激素缺乏症。
影响因子：
4.8
作者：
vanHouten,M;Rizzo,AJ;Goltzman,D;Posner,BI
通讯作者：
Posner,BI
降钙素 COOH 末端裂解肽作为鉴定重组 DNA 分析预测的新型神经肽的模型。
DOI：
--
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Amara,SG;Jonas,V;O'Neil,JA;Vale,W;Rivier,J;Roos,BA;Evans,RM;Rosenfeld,MG
通讯作者：
Rosenfeld,MG