EFFECTS OF CHRONIC AND ACUTE COCAINE TREATMENT ON THE ONSET OF MATERNAL-BEHAVIOR AND AGGRESSION IN SPRAGUE-DAWLEY RATS
EFFECTS OF CHRONIC AND ACUTE COCAINE TREATMENT ON THE ONSET OF MATERNAL-BEHAVIOR AND AGGRESSION IN SPRAGUE-DAWLEY RATS
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DOI：
10.1037/0735-7044.108.1.107
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发表时间：
1994-02-01
影响因子：
1.9
通讯作者：
PEDERSEN, CA
中科院分区：
文献类型：
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作者：
JOHNS, JM;NOONAN, LR;PEDERSEN, CA
怀孕大鼠在整个妊娠期间（GD 1-20）接受每天30 mg/kg剂量（慢性可卡因）或在分娩后立即接受一次15 mg/kg剂量（急性可卡因）。慢性和急性可卡因治疗延迟或减少了产后发病的一些组成部分的母亲的行为，和慢性治疗的大坝显着更具侵略性的男性入侵者比急性可卡因治疗或盐水治疗的大坝。在分娩后30分钟的观察期内，考马斯亮蓝增加了蹲在幼崽身上的潜伏期，并减少了蹲下的持续时间。在慢性可卡因处理的母鼠中，Lavenite到筑巢的时间也比盐水对照组长。在产后第6天，83%的慢性可卡因治疗的母鼠在10分钟的观察期内钉住并攻击入侵者雄性8次或更多次，而只有4%的急性可卡因治疗的母鼠和盐水治疗的母鼠表现出如此大的攻击性。
Pregnant rats were treated either throughout gestation (GD 1-20) with 30 mg/kg per day (chronic cocaine) or with one 15-mg/kg dose immediately following parturition (acute cocaine). Chronic and acute cocaine treatment delayed or diminished the postpartum onset of some components of maternal behavior, and chronically treated dams were significantly more aggressive toward a male intruder than acute cocaine-treated or saline-treated dams. Cocaine increased the latency to crouch over pups and decreased crouch duration during a 30-min observation period that immediately followed parturition. Latencies to nest build were also longer in more chronic cocaine-treated dams than in saline controls. On Day 6 postpartum, 83% of chronic cocaine-treated dams pinned and attacked an intruder male 8 or more times during a 10-min observation period, whereas only 4% of acute cocaine-treated and none of the saline-treated dams exhibited this much aggression.