Benzophenones and Biflavonoids from Garcinia livingstonei Fruits
Benzophenones and Biflavonoids from Garcinia livingstonei Fruits
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DOI：
10.1021/jf9046094
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发表时间：
2010-04-28
影响因子：
6.1
通讯作者：
Kennelly, Edward J.
中科院分区：
文献类型：
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作者：
Yang, Hui;Figueroa, Mario;Kennelly, Edward J.
从藤黄属植物藤黄果中鉴定出7种二苯甲酮[guttiferone A(1)、guttiferone K(2)、guttiferone K(3)、guttiferone E(4)、cycloxanthochymol(5)、isoxanthochymol(6)、gambogenone(7)1]， 5种生物黄酮[amentoflavone(8)、3,8′-biapigenin(9)、(+)-volkensiflavone（10）、(+)-morelloflavone（11）、(+)-fukugiside(12)]，以及黄酮衍生物别athyriol(13)]等13种已知化合物。化合物2 ~ 7、9、12、13均为首次在该属植物中发现。研究了二苯甲酮1和2对HCT-116、HT-29和SW-480人结肠癌细胞系的细胞毒性。两种化合物对HCT-116和HT-29细胞株的IC50值在5 ~ 10 μ M之间，对SW-480细胞的IC50值在18 ~ 25 μ M之间，活性较弱。
A series of 13 known compounds, including seven benzophenones [guttiferone A (1), guttiferone K (2), xanthochymol (3), guttiferone E (4), cycloxanthochymol (5), isoxanthochymol (6), and gambogenone (7)1, five biflavonoids [amentoflavone (8), 3,8 ''-biapigenin (9), (+)-volkensiflavone (10), (+)-morelloflavone (11), and (+)-fukugiside (12)], and the xanthone derivative alloathyriol (13), were identified from the fruits of Garcinia livingstonei (Clusiaceae). This is the first time that compounds 2-7, 9, 12, and 13 have been reported in this species. The cytotoxicity of benzophenones 1 and 2 was assessed for their effect on HCT-116, HT-29, and SW-480 human colon cancer cell lines. Both compounds exhibited strong activity against HCT-116 and HT-29 cell lines with IC50 values between 5 and 10 mu M, and somewhat weaker activity with SW-480 cells (IC50 values ranging from 18 to 25 mu M).