Effects of acute buspirone administration on inhibitory control and sexual discounting in cocaine users.
Effects of acute buspirone administration on inhibitory control and sexual discounting in cocaine users.
复制标题
急性丁螺环酮给药对可卡因使用者的抑制控制和性折扣的影响。
DOI：
10.1002/hup.2567
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Stoops,WilliamW
中科院分区：
文献类型：
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作者：
Strickland,JustinC;Bolin,BLevi;Romanelli,MichaelR;Rush,CraigR;Stoops,WilliamW
目的可卡因使用者表现出抑制控制能力不足，并做出可能增加危险行为的冲动选择。丁螺环酮是一种抗焦虑药，可激活多巴胺能和血清素能系统，并在长期服用可卡因使用者时改善冲动选择（即减少性冒险意图）。我们评估了急性施用丁螺环酮对抑制控制和冲动选择的影响。方法 11 名近期有可卡因使用史的受试者完成了这项受试者内安慰剂对照研究。受试者在口服丁螺环酮（10 和 30 毫克）、三唑仑（0.375 毫克；阳性对照）和安慰剂（阴性对照）后，执行两项提示进行/不进行和性风险延迟折扣任务。还收集了生理和精神运动表现以及受试者评分数据。结果丁螺环酮未能改变抑制控制或冲动选择；然而，在最高测试剂量下观察到反应时间较慢。丁螺环酮不会产生受试者评价的药物作用，但会剂量依赖性地降低舒张压。三唑仑会损害精神运动表现，并增加受试者评价的积极效果（例如，类似药物）的评级。结论这些研究结果表明，急性施用丁螺环酮对抑制控制和冲动性决策的行为测量几乎没有影响。考虑到之前长期给药的研究结果，这些研究结果强调丁螺环酮的行为效应随着给药条件的不同而不同。
ObjectiveCocaine users display deficits in inhibitory control and make impulsive choices that may increase risky behavior. Buspirone is an anxiolytic that activates dopaminergic and serotonergic systems and improves impulsive choice (i.e., reduces sexual risk‐taking intent) in cocaine users when administered chronically. We evaluated the effects of acutely administered buspirone on inhibitory control and impulsive choice.MethodsEleven subjects with a recent history of cocaine use completed this within‐subject, placebo‐controlled study. Subjects performed two cued go/no‐go and a sexual risk delay‐discounting task following oral administration of buspirone (10 and 30 mg), triazolam (0.375 mg; positive control), and placebo (negative control). Physiological and psychomotor performance and subject‐rated data were also collected.ResultsBuspirone failed to change inhibitory control or impulsive choice; however, slower reaction times were observed at the highest dose tested. Buspirone did not produce subject‐rated drug effects but dose‐dependently decreased diastolic blood pressure. Triazolam impaired psychomotor performance and increased ratings of positive subject‐rated effects (e.g., Like Drug).ConclusionsThese findings indicate that acutely administered buspirone has little impact on behavioral measures of inhibitory control and impulsive sexual decision‐making. Considering previous findings with chronic dosing, these findings highlight that the behavioral effects of buspirone differ as a function of dosing conditions.