Rethinking the Warburg effect with Myc micromanaging glutamine metabolism.
Rethinking the Warburg effect with Myc micromanaging glutamine metabolism.
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DOI：
10.1158/0008-5472.can-09-3556
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发表时间：
2010-02-01
期刊：
影响因子：
11.2
通讯作者：
Dang CV
中科院分区：
文献类型：
--
作者：
Dang CV
在人类癌症中经常失调的MYC癌基因编码主转录因子c-Myc（本文称为Myc），其通过其对包括微小RNA（miRNA）在内的数千个基因的调节将细胞增殖与代谢整合。除了其在调节细胞周期和葡萄糖代谢中的已知功能之外，最近的研究还记录了Myc在刺激谷氨酰胺催化剂中的作用，部分通过抑制microRNAmiR-23 a和miR-23 b。这些观察结果表明肿瘤代谢的额外复杂性，其包括肿瘤的缺氧和非缺氧区域以及周围基质之间的代谢关系。因此，在癌症代谢可以在治疗中有效靶向之前，需要考虑谷氨酰胺催化剂并更好地理解肿瘤组织学复杂性的癌症代谢的重新评估。
The MYC oncogene, which is frequently deregulated in human cancers, encodes a master transcription factor c-Myc (herein termed Myc) that integrates cell proliferation with metabolism through its regulation of thousands of genes including microRNAs (miRNAs). In addition to its known function in regulating the cell cycle and glucose metabolism, recent studies document a role for Myc in stimulating glutamine catabolism, in part through the repression of microRNAsmiR-23a and miR-23b. These observations suggest an additional level of complexity in tumor metabolism, which includes the commensal metabolic relationship between hypoxic and non-hypoxic regions of tumors as well as the surrounding stroma. Thus, a re-evaluation of cancer metabolism considering glutamine catabolism with a better understanding of the tumor histological complexity is needed before cancer metabolism can be effectively targeted in therapy.