Psychological and physiological predictors of response to carbon dioxide challenge in individuals with panic disorder.
Psychological and physiological predictors of response to carbon dioxide challenge in individuals with panic disorder.
复制标题
恐慌症患者对二氧化碳挑战反应的心理和生理预测因素。
DOI：
10.1037//0021-843x.109.4.616
复制
发表时间：
2000
影响因子：
4.6
通讯作者：
Wangensteen,OD
中科院分区：
文献类型：
--
作者：
Rassovsky,Y;Kushner,MG;Schwarze,NJ;Wangensteen,OD
过去在非临床样本中的研究发现，窒息恐惧，而不是二氧化碳(CO2)敏感性的行为指标(即屏气时间)，可以预测对二氧化碳挑战的焦虑反应。在增加了更敏感的二氧化碳敏感性指标的同时，研究了惊恐障碍患者的这些相关性。与早期的研究一致，作者发现窒息恐惧可以预测对二氧化碳挑战的焦虑反应，但屏气持续时间不会。然而，早期研究中没有包括的二氧化碳敏感度的高精度测量确实预测了焦虑的挑战反应。这些发现支持特定心理变量和生理二氧化碳敏感性对恐慌症易感性的预测价值和可能的病因学相关性。还需要进一步的工作来确定这些发现是否针对恐慌症。
Past studies in nonclinical samples have found that suffocation fear, but not a behavioral index of carbon dioxide (CO 2) sensitivity (ie, breath-holding duration), predicts anxious response to CO 2 challenge. These associations were examined in individuals with panic disorder while adding more sensitive indices of CO 2 sensitivity. Consistent with the earlier studies, the authors found that suffocation fear predicted anxious responding to CO 2 challenge but breath-holding duration did not. However, highly precise measures of CO 2 sensitivity, not included in earlier studies, did predict anxious challenge responding. These findings support the predictive value and possible etiological relevance of both specific psychological variables and physiological CO 2 sensitivity in panic vulnerability. Further work is still needed to determine whether the findings are specific to panic disorder.