A hypothermic-temperature-sensitive gene silencing by the mammalian RNAi
A hypothermic-temperature-sensitive gene silencing by the mammalian RNAi
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DOI：
10.1016/j.bbrc.2004.01.097
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发表时间：
2004-03-12
影响因子：
3.1
通讯作者：
Sugiyama, T
中科院分区：
文献类型：
--
作者：
Kameda, T;Ikegami, K;Sugiyama, T
RNA interference (RNAi) has been attracting a great deal of attention. This pathway is highly conserved among most eukaryotes and believed to be important for antiviral reactions and epigenetic gene regulation. Because a temperature-sensitive RNAi was reported in both plant and insect systems, suggesting its evolutional conservation, we analyzed the effect of different temperatures on mammalian RNAi, targeting the ectopic gene expression, and detected suppression at hypothermic temperatures. This phenomenon could be critical and useful to control ectopic and internal gene expressions by RNAi. (C) 2004 Elsevier Inc. All rights reserved.
