Basal ganglia shape alterations in bipolar disorder
Basal ganglia shape alterations in bipolar disorder
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DOI：
10.1176/appi.ajp.163.2.276
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发表时间：
2006-02-01
影响因子：
17.7
通讯作者：
Renshaw, PF
中科院分区：
文献类型：
--
作者：
Hwang, J;Lyoo, IK;Renshaw, PF
目的：应用球谐(SPHARM)技术比较药物治疗前后双相情感障碍患者和健康对照组尾状核头部和壳核的形态差异。在前人研究的基础上，作者假设药物初治者与健康对照组相比，尾状核头部和壳核的形态差异较大，尤其是右侧；相对于健康对照组，药物初治者和药物治疗组的形状差异也不同。方法：对49例双相情感障碍患者(21例药物初治者和28例药物治疗组)和37例健康对照组进行脑磁共振成像。用SPHARM描述法测量各组间尾状头和壳核表面的体积差异。结果：虽然组间纹状体结构的体积差异不显著，但在纹状体的前表面和腹面有显著的形态差异。与健康对照组相比，未用药的双相情感障碍患者的纹状体形态差异更明显，而药物治疗的双相情感障碍患者纹状体的形态差异不明显。结论：药物未用药的双相情感障碍患者纹状体的形态与健康对照相比存在差异，这种差异可能通过治疗来调节。这些发现更普遍地证明了SPHARM分析技术在没有体积差异的情况下检测小脑区细微解剖形状差异的敏感性。
Objective: Shape differences in the caudate heads and putamen were compared between drug-naive and drug-treated patients with bipolar disorder and healthy comparison subjects by using spherical harmonic (SPHARM) techniques. On the basis of previous studies, the authors hypothesized that the drug-naive patients would exhibit shape differences of the caudate heads and putamen, especially on the right side, relative to the healthy comparison subjects, and that shape differences, relative to healthy comparison subjects, would differ between drug-naive and drug-treated patients.Method: Brain magnetic resonance images were acquired from 49 bipolar disorder patients (21 drug-naive and 28 drug-treated patients) and 37 healthy comparison subjects. Volumetric measurements were obtained, and SPHARM descriptions were used to measure between-group radius differences in the surfaces of the caudate heads and putamen.Results: Although no significant between-group volume differences were found in the striatal structures, significant shape differences in the anterior and ventral surfaces of the striatum were observed. Specifically, shape differences, more prominent for the right side, were found for drug-naive bipolar disorder patients, relative to the healthy comparison subjects, but not for drug-treated bipolar disorder subjects.Conclusions: The findings suggest that drug-naive bipolar disorder patients have shape differences of the striatum, relative to healthy comparison subjects, and that these differences may be modulated by treatment. The findings more generally demonstrate the sensitivity of the SPHARM analytic technique for detecting subtle anatomical shape differences in small brain regions in the absence of volume differences.