Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years
Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years
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DOI：
10.1542/peds.2006-1379
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发表时间：
2006-12-01
期刊：
影响因子：
8
通讯作者：
Marceau, Picard
中科院分区：
文献类型：
--
作者：
Kral, John G.;Biron, Simon;Marceau, Picard
目标。我们的目标是比较172名2至18岁的肥胖母亲(BMI：31+/-9 kg/m(2))和45名同龄兄弟姐妹(母亲的BMI：48+/-8 kg/m(2))与当前人口标准的肥胖患病率。在第三转诊中心的88%的随访、横断面办公室图表和关于儿童和青少年体重的电话数据被转换为z分。结果：母亲手术后，子女肥胖的患病率下降了52%，重度肥胖的患病率下降了45.1%，体重不足的患病率没有增加。肥胖的z得分下降是性别特有的，男孩从母亲手术前的1.4+/-1.3下降到母亲手术后的0.57+/-1.7，修正了出生顺序。女生差异不显著(0.8+/-1.3比0.8+/-1.2)。在6-18岁的母亲手术后出生的儿童中，超重的患病率被降低到人群水平。结论：与宫内营养不足和过度营养的结果相反，术后自愿体重大幅下降的母亲的儿童超重和肥胖的患病率与普通人群相似，但体重不足的发生率没有增加。这些结果证明了潜在的可改变的表观遗传因素在肥胖原因中的重要性。
OBJECTIVE. Our aim was to compare the prevalence of obesity in 172 children who were aged 2 to 18 years and born to 113 obese mothers (BMI: 31 +/- 9 kg/m(2)) with substantial weight loss after biliopancreatic bypass surgery with 45 same-age siblings who were born before maternal surgery (mothers' BMI: 48 +/- 8 kg/m(2)) and with current population standards.METHODS. In this case series, with > 88% follow-up in a tertiary referral center, cross-sectional office chart and telephone data on childhood and adolescent weights were transformed to z scores.RESULTS. After maternal surgery, the prevalence of obesity in the offspring decreased by 52% and severe obesity by 45.1%, with no increase in the prevalence of underweight. The z score reduction in obesity was gender specific, with boys reducing from 1.4 +/- 1.3 before to 0.57 +/- 1.7 after maternal surgery, corrected for birth order. The difference was not significant in girls (0.8 +/- 1.3 vs 0.8 +/- 1.2). Among children of both genders who were aged 6 to 18 years of age and born after maternal surgery, the prevalence of overweight was reduced to population levels.CONCLUSIONS. Contrary to outcomes after intrauterine under- and overnutrition, the prevalence of overweight and obesity in children of mothers with large voluntary postsurgical weight loss was similar to that in the general population, with no increase in underweight. The results demonstrate the importance of potentially modifiable epigenetic factors in the cause of obesity.