HAS THE CELLULAR PROLIFERATION MARKER KI67 ANY CLINICAL RELEVANCE IN SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
HAS THE CELLULAR PROLIFERATION MARKER KI67 ANY CLINICAL RELEVANCE IN SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK
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DOI：
10.1111/j.1365-2273.1994.tb01140.x
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发表时间：
1994-02-01
影响因子：
2.1
通讯作者：
JONES, AS
中科院分区：
文献类型：
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作者：
ROLAND, NJ;CASLIN, AW;JONES, AS
多年来，许多实验室因素已被研究，以期预测头颈癌的过程。由于缺乏成功，促使人们将细胞动力学的各种测量方法应用于这一主题。本研究包括79例经证实的头颈部不同部位鳞状细胞癌患者，并进行了各种治疗。使用抗生物素蛋白-生物素复合物方法进行Ki 67染色，并记录每1000个肿瘤细胞的计数。患者的平均年龄为61岁，5年生存率为54%（95%CI，29-73%）。Ki 67指数中位数为278，代表每1000个肿瘤细胞中阳性染色的细胞数。最小染色为82，最大染色为808，下四分位数为95，上四分位数为452。Ki 67指数未能与任何宿主或肿瘤因子相关。此外，中位Ki 67值在辐照组织和非辐照组织之间、部位之间以及后来发生淋巴结转移和未发生淋巴结转移的患者之间没有显著差异。特别相关的是Ki 67值与存活率不相关。使用考克斯生存比例风险模型进一步分析数据。Ki 67对存活率没有显著影响。结论：Ki 67指数对头颈部鳞癌的预后无预测价值。
Over the years many laboratory factors have been studied with a view to predicting the course of head and neck cancer. The lack of success prompted the application of various measures of cell kinetics to this topic. The present study includes 79 patients with a proven squamous cell carcinoma of the head and neck at various sites and having various treatments. Ki67 staining was carried out using the avidin-biotin complex method and counts recorded per 1000 tumour cells. The patients' mean age was 61 years and the 5 year survival was 54% (95% Cl, 29-73%). The median Ki67 index was 278 representing the number of cells stained positively per 1000 tumour cells. The minimum staining was 82 and the maximum 808 with a lower quartile of 95 and an upper quartile of 452. The Ki67 index failed to correlate with any host or tumour factors. In addition, median Ki67 values were not significantly different between irradiated tissue and non-irradiated tissue, between sites nor between patients who did and did not later develop lymph-node metastases. Of particular relevance is that Ki67 value did not correlate with survival. Data was further analysed using Cox's proportional hazards model for survival. Ki67 had no significant effect on survival. It is concluded that Ki67 index is of no value in predicting the course of squamous cell carcinoma of the head and neck.