Dermatophytoma caused by terbinafine‐resistant Trichophyton rubrum treated with fosravuconazole
Dermatophytoma caused by terbinafine‐resistant Trichophyton rubrum treated with fosravuconazole
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福斯拉康唑治疗耐特比萘芬红色毛癣菌引起的皮肤癣菌
DOI：
10.1111/1346-8138.16480
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
R. Kano
中科院分区：
文献类型：
--
作者：
H. Noguchi;Tadahiko Matsumoto;Masahide Kubo;Utako Kimura;M. Hiruma;T. Yaguchi;Tsuyoshi Yamada;R. Kano
亲爱的编辑，特比萘芬耐药皮肤真菌菌株在过去十年中在全球范围内增加。我们成功地治疗了一例由特比萘芬耐药红色毛癣菌引起的甲状旁腺炎患者（角鲨烯环氧酶中的Phe 397 Leu取代;因此，1998年，皮肤真菌瘤被描述为一种独特类型的甲真菌病，见于一些远端和侧甲下甲真菌病，其特征是密集的皮肤真菌菌丝丛和大的节孢子，或两者兼而有之，通过KOH法观察真菌聚集体，在显微镜下进行诊断。皮肤癣菌瘤对标准的口服抗真菌药物是无效的。红色与口服福唑康唑。一名81岁的男性农民患有2型糖尿病（血红蛋白A1 c，7.0%），于2020年6月因臀部不适来到我们的诊所。他定期服用阿司匹林、阿司匹林和奥美沙坦。经鉴定为特比萘芬耐药T.缢虫
Dear Editor, Terbinafineresistant dermatophyte strains have increased over the past decade worldwide. We successfully treated a patient with tinea unguium caused by a terbinafineresistant Trichophyton rubrum (Phe397Leu substitution in squalene epoxidase; SQLE).1 Therewith, dermatophytoma was described in 1998 as a unique type of tinea unguium seen in some distal and lateral subungual onychomycosis, characterized by densely packed clump of dermatophyte hyphae and large arthroconidia, or both, compacted and forming a fungal ball.2 Definitive diagnosis is made microscopically by observation of fungal conglomerate via KOH method. Dermatophytomas are recalcitrant to standard oral antifungal medications.2 Herein, we treated a patient with dermatophytoma caused by terbinafineresistant T. rubrum with oral fosravuconazole. An 81yearold male farmer with type 2 diabetes (hemoglobin A1c, 7.0%) presented to our clinic with tinea corporis (buttocks) in June 2020. He was taking aspirin, amlodipine, and olmesartan regularly. The isolate was identified as terbinafineresistant T. rubrum