ELECTRICALLY EVOKED WHOLE-NERVE ACTION-POTENTIALS - DATA FROM HUMAN COCHLEAR IMPLANT USERS
ELECTRICALLY EVOKED WHOLE-NERVE ACTION-POTENTIALS - DATA FROM HUMAN COCHLEAR IMPLANT USERS
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DOI：
10.1121/1.399716
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发表时间：
1990-09-01
影响因子：
2.4
通讯作者：
GANTZ, B
中科院分区：
文献类型：
--
作者：
BROWN, CJ;ABBAS, PJ;GANTZ, B
本研究描述了一种记录 Ineraid 人工耳蜗使用者的电诱发全神经动作电位 (EAP) 的方法。该方法是对 Charlet de Sauvage 等人最初使用的方法的改编。 [J。声学。苏克。是。 73, 615-627 (1983)] 在豚鼠中。 11 名受试者记录的响应由单个负峰值组成，该峰值的延迟时间约为 0.4 毫秒。 EAP 输入/输出函数是陡峭且单调的。已记录的响应幅度高达 160 μV。 EAP 输入/输出函数的斜率与测量单词识别技能的测试结果有一定的相关性（大约 0.6-0.69）。还评估了听觉神经的难治特性。不同受试者从难治性状态的恢复率存在差异。这些发现意味着，不同受试者在听觉神经水平上编码快速时间线索的准确性可能存在差异。在这些恢复曲线的斜率大小和单词识别测试的性能之间发现了相当强的相关性（大约 0.74-0.85）。
This study describes a method for recording the electrically evoked, whole-nerve action potential (EAP) in users of the Ineraid cochlear implant. The method is an adaptation of one originally used by Charlet de Sauvage et al. [J. Acoust. Soc. Am. 73, 615-627 (1983)] in guinea pigs. The response, recorded from 11 subjects, consists of a single negative peak that occurs with a latency of approximately 0.4 ms. EAP input/output functions are steeply sloping and monotonic. Response amplitudes ranging up to 160 .mu.V have been recorded. Slope of the EAP input/output function correlates modestly (approximately 0.6-0.69) with results of tests measuring word recognition skills. The refractory properties of the auditory nerve were also assessed. Differences across subjects were found in the rate of recovery from the refractory state. These findings imply that there may be difference across subjects in the accuracy with which rapid temporal cues can be coded at the level of the auditory nerve. Reasonably strong correlations (approximately 0.74-0.85) have been found between the magnitude of the slope of these recovery curves and performance on tests of word recognition.