CORTICAL-CELLS THAT MIGRATE BEYOND AREA BOUNDARIES - CHARACTERIZATION OF AN EARLY NEURONAL POPULATION IN THE LOWER INTERMEDIATE ZONE OF PRENATAL RATS
CORTICAL-CELLS THAT MIGRATE BEYOND AREA BOUNDARIES - CHARACTERIZATION OF AN EARLY NEURONAL POPULATION IN THE LOWER INTERMEDIATE ZONE OF PRENATAL RATS
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DOI：
10.1111/j.1460-9568.1994.tb00593.x
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发表时间：
1994-06-01
影响因子：
3.4
通讯作者：
FAIREN, A
中科院分区：
文献类型：
--
作者：
DEDIEGO, I;SMITHFERNANDEZ, A;FAIREN, A
对哺乳动物大脑皮层早期发育的研究表明，形成原始丛状层(也称为前板或边缘区)的最早产生的神经元分布在I层和VII层(亚板)之间。通过有丝分裂后细胞的溴脱氧尿嘧啶核苷标记，我们发现，在大鼠中，原始丛状层的另一组神经元仍留在脑室带附近。这一发现与Marin-Padilla(Z.Anat.Entwicklugsgesch，134,117-145,1971)，暗示了原始网状层在皮质板层和中间带(后者很快成为胚胎白质)形成后经历了三个分裂。因此，原始丛状层衍生物位于第一层、第七层(亚板)和胚胎白质的下部。这种早期产生的神经元群体也被发现有一种抗体可以识别更大的(67 KDa)谷氨酸脱羧酶亚型(Kaufman等人，Science，232,1138-1140,1986)。这与早先发现的含有GABA的细胞群体呈现类似的时空分布是一致的。早期生成的胚胎白质神经元呈切线迁移，在出生后早期的动物中，在皮质下白质的内侧区域和胼胝体的中线处可发现间质细胞。在尾部水平，类似的细胞侵入发育中的海马体锥体下层。这种切向迁移可能解释了最近大脑皮层细胞谱系研究中描述的神经细胞克隆的切向分散。
Studies of the early development of the mammalian cerebral cortex have revealed that the earliest generated neurons that form the primordial plexiform layer (also called preplate or marginal zone) distribute among layer I and layer VII (subplate). By means of bromodeoxyuridine labelling of cells becoming postmitotic, we have found evidence that, in the rat, an additional group of neurons of the primordial plexiform layer remains in the close vicinity of the ventricular zone. This finding, in line with the proposal by Marin-Padilla (Z. Anat. Entwicklungsgesch., 134, 117-145, 1971), implies that the primordial plexiform layer suffers a tripartition after the formation of the cortical plate and of the intermediate zone (the latter soon becomes the embryonic white matter). Thus, primordial plexiform layer derivatives are in layer I, layer VII (subplate) and in the lower part of the embryonic white matter. This early generated neuronal population is also revealed with an antibody that recognizes the larger (67 kDa) isoform of glutamic acid decarboxylase (Kaufman et al., Science, 232, 1138-1140, 1986). This is in accord with the earlier finding of a GABA-containing cell population showing a similar spatiotemporal distribution. The early generated neurons of the embryonic white matter migrate tangentially and, in early postnatal animals, are found as interstitial cells in the medial regions of the subcortical white matter and at the midline in the corpus callosum. At caudal levels, similar cells invade the subpyramidal strata of the developing hippocampus. This tangential migration might explain the tangential dispersion of neural cell clones described in recent studies of cell lineage in the cerebral cortex.