Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis
Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis
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DOI：
10.1038/nmat1233
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发表时间：
2004-11-01
期刊：
影响因子：
41.2
通讯作者：
Kawaguchi, H
中科院分区：
文献类型：
--
作者：
Moro, T;Takatori, Y;Kawaguchi, H
假体周围骨溶解-假体附近的骨丢失-是限制人工关节寿命的最严重问题。这是由于对关节面产生的磨损颗粒的骨吸收反应引起的。本研究探讨了我们原来的生物相容性磷脂聚合物2-甲基丙烯酰氧乙基磷酰胆碱（MPC）到聚乙烯表面的接枝聚合的影响。使用髋关节模拟器进行的力学研究表明，MPC移植物显著降低了摩擦力和磨损量。将MPC移植到颗粒上，可以消除颗粒骨膜下注射到小鼠颅骨上引起的骨吸收。培养系统表明，MPC移植颗粒在巨噬细胞的吞噬作用和再吸收细胞因子分泌、成骨细胞中NF-kappaB配体受体激活剂的后续表达以及骨髓细胞的破骨细胞生成方面具有生物惰性。从机械和生物学的优势，我们相信，我们的方法将作出重大改进，人工关节，防止假体周围骨溶解。
Periprosthetic osteolysis-bone loss in the vicinity of a prosthesis-is the most serious problem limiting the longevity of artificial joints. It is caused by bone-resorptive responses to wear particles originating from the articulating surface. This study investigated the effects of graft polymerization of our original biocompatible phospholipid polymer 2-methacryloyloxyethyl phosphorylcholine (MPC) onto the polyethylene surface. Mechanical studies using a hip-joint simulator revealed that the MPC grafting markedly decreased the friction and the amount of wear. Osteoclastic bone resorption induced by subperiosteal injection of particles onto mouse calvariae was abolished by the MPC grafting on particles. MPC-grafted particles were shown to be biologically inert by culture systems with respect to phagocytosis and resorptive cytokine secretion by macrophages, subsequent expression of receptor activator of NF-kappaB ligand in osteoblasts, and osteoclastogenesis from bone marrow cells. From the mechanical and biological advantages, we believe that our approach will make a major improvement in artificial joints by preventing periprosthetic osteolysis.