Plasma levels of adrenomedullin, a vasoactive peptide, in type 2 diabetic patients with and without retinopathy.
Plasma levels of adrenomedullin, a vasoactive peptide, in type 2 diabetic patients with and without retinopathy.
复制标题
患有或不患有视网膜病变的 2 型糖尿病患者的血浆肾上腺髓质素（一种血管活性肽）水平。
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Claudio Letizia
中科院分区：
文献类型：
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作者：
C. Caliumi;Stefano Balducci;L. Petramala;D. Cotesta;L. Zinnamosca;Rossella Cianci;D. D. Donato;E. Vingolo;Francesco Fallucca;Claudio Letizia
目的
本研究的目的是调查是否肾上腺髓质素（AM）分泌的2型糖尿病患者和无视网膜病变的修改。
方法
该研究对92名2型糖尿病患者进行了研究，其中65名患有单纯性糖尿病，27名患有视网膜病变，40名患有轻度至中度高血压。排除血清肌酐水平> 1.2 mg/dL的患者。采用特异性放射免疫分析法测定循环AM。
结果
2型糖尿病患者的AM浓度（25 ± 2.1 pg/mL）显著高于31名正常人（11 ± 0.8 pg/mL）（P <0.001）。伴有视网膜病变的2型糖尿病患者AM水平（30.8 ± 3.4 pg/mL）显著高于对照组（P <0.001）和无视网膜病变的2型糖尿病患者（25.2 ± 2 pg/mL，与先前值相同）（P <0.001）。糖尿病患者增殖前视网膜病变（27.3 +/-4.7 pg/mL）和增殖性视网膜病变（24 +/-3.1 pg/mL）之间无统计学差异（P = 0.543）。2型糖尿病患者血浆AM水平与HbA1c值呈显著正相关（r = 0.467; P <0.01）。
结论
我们的研究结果表明，2型糖尿病患者的循环AM增加，并且这种增加与葡萄糖代谢控制不良和视网膜病变的存在相关。
AIM
The aim of this study was to investigate whether adrenomedullin (AM) secretion is modified in type 2 diabetic patients with and without retinopathy.
METHODS
The study was performed on 92 patients with type 2 diabetes, 65 of whom had uncomplicated diabetes, 27 had retinopathy, and 40 had mild to moderate hypertension. Patients with serum creatinine levels >1.2 mg/dL, were excluded. Circulating AM was assayed using a specific radioimmunoassay.
RESULTS
AM concentrations were significantly higher in type 2 diabetic patients (25+/-2.1 pg/mL) than in the 31 normal subjects (11+/-0.8 pg/mL) (P<0.001). Type 2 diabetic patients with retinopathy had significantly greater AM levels (30.8+/-3.4 pg/mL) than both controls (P<0.001) and type 2 diabetic patients without retinopathy (25.2+/-2 pg/mL same as previous value) (P<0.001). No statistical difference was found between diabetic patients with pre-proliferative retinopathy (27.3+/-4.7 pg/mL) and proliferative retinopathy (24+/-3.1 pg/mL) (P=0.543). In type 2 diabetic patients, a significant correlation between plasma AM levels and HbA1c values (r=0.467; P<0.01) was found.
CONCLUSION
Our findings indicate that circulating AM is increased in type 2 diabetic patients and that increase correlates with poor glucose metabolic control and presence of retinopathy.