Helicobacter pylori-associated chronic atrophic gastritis involving the gastric body and severe disease by Vibrio cholerae.
Helicobacter pylori-associated chronic atrophic gastritis involving the gastric body and severe disease by Vibrio cholerae.
复制标题
幽门螺杆菌相关的慢性萎缩性胃炎累及胃体和霍乱弧菌引起的严重疾病。
DOI：
10.1016/j.trstmh.2005.09.013
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发表时间：
2006
影响因子：
2.2
通讯作者：
Gilman,RobertH
中科院分区：
文献类型：
--
作者：
León-Barúa,Raúl;Recavarren-Arce,Sixto;Chinga-Alayo,Erick;Rodríguez-Ulloa,Carlos;Taylor,DavidN;Gotuzzo,Eduardo;Kosek,Margaret;Eza,Dominique;Gilman,RobertH
Evidence has associated chronic infection byHelicobacter pyloriwith chronic gastritis, low gastric acid production and an increased risk of life-threatening cholera. However, the relationship of specific patterns of histological damage in the gastric mucosa associated withH. pyloriinfection and the occurrence of cholera has not been described. The purpose of this study was to compare the gastric pH and histopathological findings in gastric biopsies taken from patients with severe diarrhoeal disease due toVibrio choleraewith those taken from a control (cholera-negative) population. Thirty-fiveH. pylori-positive patients who had severe dehydration from culture-confirmed cholera (cases) and 40 patients withH. pyloribut with no history of cholera (controls) were recruited. Gastric pH was measured and multiple biopsies were taken from the gastric antrum and body for histopathological examination. The results revealed that patients with severe cholera had a significantly higher prevalence of hypochlorhydria at endoscopy compared with controls. Furthermore, cases had significantly more chronic atrophic gastritis (45.7% vs. 12.5%;P= 0.002) and intestinal metaplasia (37.1% vs. 2.5%;P< 0.01) in the gastric body than controls. Our findings suggest that the nature and location of these gastric lesions may predispose a subset ofH. pylori-infected individuals to severe disease byV. cholerae.
