The similarity index and DNA fingerprinting.
The similarity index and DNA fingerprinting.
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DOI：
10.1093/oxfordjournals.molbev.a040620
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发表时间：
1990-09
影响因子：
10.7
通讯作者：
Michael Lynch
中科院分区：
文献类型：
--
作者：
Michael Lynch
DNA指纹相似性越来越多地被用来推断自然种群内部和之间的遗传变异水平。结果表明，相似性指数--共享限制性片段的平均比例--提供了对群体纯合性的向上偏向估计，但对随机个体对的平均状态同一性提供了近乎无偏的估计。提出了一种将DNA指纹差异性划分为种群内和种群间分量的方法。给出了这些估计量的抽样方差的一些简单表达式。
DNA-fingerprint similarity is being used increasingly to make inferences about levels of genetic variation within and between natural populations. It is shown that the similarity index--the average fraction of shared restriction fragments--provides upwardly biased estimates of population homozygosity but nearly unbiased estimates of the average identity-in-state for random pairs of individuals. A method is suggested for partitioning the DNA-fingerprint dissimilarity into within- and between-population components. Some simple expressions are given for the sampling variances of these estimators.